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Updated: Jan 30, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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Requisitos moleculares para la activación de PLK1 por fosforilación de T-loop

Arianna Esposito-Verza1,2, Duccio Conti3, Paulo D Rodrigues Pedroso3,4

  • 1Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany. arianna.espositoverza@mpi-dortmund.mpg.de.

The EMBO journal
|January 28, 2026
PubMed
Resumen

La quinasa mitótica maestra PLK1 requiere fosforilación para su activación. Este estudio revela que Bora, el compañero de Aurora A, es el único necesario para la fosforilación de PLK1 Thr210, lo que descubre un mecanismo clave de especificidad.

Palabras clave:
AuroraCiclo CelularQuinasaPolo-like Kinasecinetocoro

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