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Nanocristalización y Microencapsulación de Pigmentos Naturales para Mejorar la Disolución y Estabilidad
Zhitao Cai1, Hanyan Gong1, Sishu Li1
1School of Pharmacy, Shenyang Pharmaceutical University, Shenhe District, No. 103 Wenhua Road, Wulihe Subdistrict, 110016, Shenyang, Liaoning, People's Republic of China.
AAPS PharmSciTech
|January 29, 2026
Resumen
Un novedoso sistema de nanosuspensión-microencapsulación mejora significativamente la disolución, estabilidad y procesamiento de pigmentos lipofílicos naturales como la curcumina y la luteína para uso farmacéutico.
Área de la Ciencia:
- Ciencias Farmacéuticas; Ciencia de Materiales; Nanotecnología
Sus antecedentes:
- Los pigmentos lipofílicos naturales (p. ej., curcumina, luteína) tienen baja solubilidad en agua, bajas tasas de disolución e inestabilidad fototérmica, lo que limita sus aplicaciones farmacéuticas.; El desarrollo de sistemas de administración eficaces es crucial para mejorar la biodisponibilidad y la estabilidad de estos valiosos compuestos.
Objetivo del estudio:
- Desarrollar y optimizar un sistema de administración de nanosuspensión-microencapsulación para pigmentos lipofílicos naturales.; Mejorar la disolución, estabilidad y propiedades del polvo de curcumina y luteína para la formulación farmacéutica.
Principales métodos:
- Se prepararon nanosuspensiones (NS) de curcumina (CUR) y luteína (LUT) mediante precipitación con antisolvente y se optimizaron con molienda en medio húmedo, utilizando Hidroxipropil metilcelulosa E5 (HPMC-E5) como estabilizador.; Las nanosuspensiones se convirtieron en microcápsulas mediante secado por aspersión y recubrimiento en lecho fluidizado con núcleos a base de sacarosa.; Se evaluaron la modificación de la superficie y las propiedades del polvo (fluidez, compresibilidad).
Principales resultados:
- La curcumina-NS y la luteína-NS mostraron tasas de disolución significativamente mejoradas en comparación con los pigmentos crudos (CUR-NS: 93,3% en 5 min; LUT-NS: 85,1% en 120 min).; La microencapsulación mediante recubrimiento en lecho fluidizado produjo microcápsulas con excelente fluidez (ángulo de reposo ~20°) y aptitud para la compresión directa.; Las pruebas de estabilidad acelerada demostraron mejoras de 1,3 a cuatro veces en la resistencia al calor, la luz y la humedad para las microcápsulas en comparación con los pigmentos crudos.
Conclusiones:
- La estrategia desarrollada de nanosuspensión-microencapsulación mejora eficazmente la disolución, la estabilidad y el rendimiento del procesamiento de pigmentos naturales poco solubles.; Este enfoque muestra una promesa significativa para la formulación y aplicación industrial de pigmentos naturales en productos farmacéuticos.
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