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Updated: Jun 9, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Alteraciones del plexo coroideo en COVID persistente y sus asociaciones con los riesgos de la enfermedad de Alzheimer
Huize Pang1, Jennifer Frontera2, Li Jiang1
1Department of Radiology, NYU Grossman School of Medicine, New York, New York, USA.
Introduction:
Choroid plexus (ChP) enlargement is a neuroimaging biomarker of neuroinflammation and neurodegeneration. However, evidence of ChP structural and perfusion alterations in long coronavirus disease (COVID) and their clinical relevance remains limited.
Methods:
This study included 86 long COVID, 67 recovered COVID, and 26 COVID-negative healthy controls (HCs). ChP volume and cerebral blood flow (CBF) were quantified, and their associations with Alzheimer's disease (AD) symptoms and plasma biomarkers were examined.
Results:
Both patient groups showed higher ChP volume and lower CBF than HC. Relative to recovered COVID, long COVID patients had a larger ChP volume, but no significant difference in CBF. ChP volume correlated positively with glial fibrillary acidic protein (r = 0.35) and phosphorylated tau217 (p-tau217; r = 0.54), while CBF correlated negatively with p-tau217 (r = -0.56). Both ChP volume and CBF were associated with cognitive decline measured with Mini-Mental State Examination and Clinical Dementia Rating.
Discussion:
These findings suggest that ChP differences in long COVID are associated with AD-related cognitive decline and increased plasma biomarkers.
Highlights:
Long coronavirus disease (COVID) patients show choroid plexus (ChP) enlargement and reduced cerebral blood flow. ChP alterations are associated with Alzheimer's disease (AD)-related symptoms and plasma biomarker changes. ChP alterations on magnetic resonance imaging may serve as imaging markers for tracking neurological symptoms and AD-related pathology in post-COVID patients.
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