Video Experimental Relacionado

Updated: Jan 31, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Diarrea y colitis inmunomediadas con hallazgos bioquímicos, endoscópicos e histológicos normales: un estudio

Malek Shatila¹, Sharada Wali¹, Carolina Colli Cruz¹

¹The University of Texas MD Anderson Cancer Center, Department of Gastroenterology, Hepatology, and Nutrition, Houston, TX (Malek Shatila, Sharada Wali*, Carolina Colli Cruz*, Krishnavathana Varatharajalu, Anusha Shirwaiker Thomas, Yinghong Wang).

Annals of gastroenterology

|January 30, 2026

Resumen

La diarrea y colitis inmunomediadas (DCIM) sin marcadores de inflamación se asocia con inhibidores de PD-1/PD-L1. Estos pacientes experimentan síntomas más leves y menos hospitalizaciones, aunque algunos aún necesitan inmunosupresión.

Área de la Ciencia:

Oncología; Gastroenterología; Inmunología

Sus antecedentes:

La diarrea y colitis inmunomediadas (DCIM) pueden ocurrir con los inhibidores de puntos de control.; Un subconjunto de pacientes se presenta con DCIM pero carece de biomarcadores fecales, evidencia endoscópica o histológica de inflamación.; La comprensión del tratamiento y los resultados para este grupo específico de DCIM es limitada.

Objetivo del estudio:

Describir las características de los pacientes con DCIM sin evidencia de inflamación.; Aclarar el papel de los tratamientos inmunosupresores en el manejo de este subconjunto de DCIM.; Investigar los posibles vínculos entre los inhibidores de PD-1/L1 y esta presentación específica de DCIM.

Principales métodos:

Estudio retrospectivo unicéntrico.; Criterios de inclusión: pacientes tratados con inhibidores de puntos de control inmunitario que desarrollaron síntomas clínicos de DCIM sin evidencia de inflamación (calprotectina fecal, endoscopia, histología).; Período de estudio: enero de 2010 a febrero de 2024.

Principales resultados:

El 11,4 % de los pacientes con DCIM (131/1151) no mostraron inflamación.; Estos pacientes tuvieron una mayor exposición a agentes PD-1/L1 y una diarrea menos grave, con menores tasas de hospitalización.; Aproximadamente el 40 % requirió tratamiento inmunosupresor, sin diferencias significativas en los síntomas o la gravedad entre los que lo recibieron y los que no.

Conclusiones:

Este es el primer estudio sobre DCIM con marcadores de inflamación normales.; La inhibición de PD-1/L1 puede predisponer a esta forma de DCIM, asociada con resultados más leves.; A pesar de la presentación más leve, el tratamiento inmunosupresor a menudo es necesario, y algunos pacientes pueden desarrollar posteriormente inflamación colónica.

Palabras clave:

Diarrea y colitis inmunomediadas inmunoterapia infliximab vedolizumab

Más Videos Relacionados

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS

Published on: September 11, 2012

Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds

Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds

Published on: October 20, 2012

Videos de Conceptos Relacionados

Endoscopic Studies II: Thoracocentesis

Endoscopic Studies II: Thoracocentesis

Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

Finding the Center of Gravity

Finding the Center of Gravity

The center of gravity of a body is an imaginary point where the body's total weight is assumed to be concentrated, and the body is perfectly balanced. The center of the mass of a body is a point at which the whole of the mass of the body appears to be concentrated. If the acceleration due to gravity, g, has the same value at all points on a body, its center of gravity is identical to its center of mass. The center of gravity of homogeneous bodies such as a sphere, cube, or rectangular plate...