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Granulomatosis con Poliangeítis con Afectación Hepática
Asmita Poudel1, Prajwal Adhikari2, Vaibhav Sundaresan1
1General Internal Medicine, Northern General Hospital, Sheffield, GBR.
Cureus
|January 30, 2026
Resumen
La Granulomatosis con Poliangeítis (GPA), una vasculitis autoinmune, puede afectar el hígado. Este informe de caso destaca los desafíos diagnósticos de la GPA que se presenta con afectación hepática y síntomas constitucionales.
Área de la Ciencia:
- Inmunología
- Reumatología
- Gastroenterología
Sus antecedentes:
- La Granulomatosis con Poliangeítis (GPA) es una vasculitis autoinmune rara.
- Los neutrófilos están implicados en la patogenia de la GPA.
- La GPA afecta comúnmente el tracto respiratorio superior, los pulmones y los riñones, pero ocasionalmente se reporta afectación hepática.
Objetivo del estudio:
- Presentar un caso de GPA con afectación hepática.
- Destacar los desafíos diagnósticos de la GPA que se presenta con disfunción hepática.
Principales métodos:
- Presentación de un informe de caso.
- Revisión de la presentación clínica, hallazgos de laboratorio y proceso diagnóstico.
Principales resultados:
- Un hombre de mediana edad presentó síntomas constitucionales y pruebas de función hepática anormales.
- El paciente fue finalmente diagnosticado con GPA que involucraba el hígado.
Conclusiones:
- La afectación hepática en la GPA puede presentarse de forma insidiosa con síntomas constitucionales y pruebas de función hepática alteradas.
- El reconocimiento y diagnóstico tempranos de la GPA con afectación hepática son cruciales para un manejo oportuno y la prevención de resultados graves.
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