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Selección Natural Guiada por Imágenes Moleculares Dirigidas a ACE2: Un Nuevo Paradigma para el Desarrollo de
1Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai 200433, China.
Chemical & biomedical imaging
|January 30, 2026
Resumen
Los investigadores desarrollaron un nuevo péptido, Omi-X, para la obtención de imágenes no invasivas de la enzima convertidora de angiotensina 2 (ACE2). Este péptido permite un mapeo preciso de la expresión de ACE2, lo que ayuda en el diagnóstico y tratamiento de enfermedades relacionadas con el sistema renina-angiotensina.
Área de la Ciencia:
- Imagen Biomédica
- Biología Molecular
- Descubrimiento de Fármacos
Sus antecedentes:
- La enzima convertidora de angiotensina 2 (ACE2) es un biomarcador crítico y una diana terapéutica para diversas enfermedades.
- La visualización in vivo no invasiva de ACE2 es esencial para el manejo de enfermedades y la evaluación del tratamiento.
Objetivo del estudio:
- Desarrollar una molécula diana peptídica de alta afinidad para ACE2.
- Permitir la obtención de imágenes PET no invasivas para el mapeo de ACE2 y la evaluación de enfermedades relacionadas.
Principales métodos:
- Cribado de bibliotecas de péptidos RBD de variantes de Omicron (BA.1, BA.2, BA.5) mediante radioinmunoensayo.
- Cribado de alto rendimiento basado en la unión a células HEK293-hACE2 y verificación de acoplamiento molecular.
- Desarrollo de trazadores de imágenes SPECT y PET (125I-Omi-X y 68Ga-DOTA-Omi-X) para biodistribución y mapeo de ACE2 in vivo.
Principales resultados:
- Se identificó Omi-X (505HQPYRVVVLSFELLH519) con una afinidad de unión superior a ACE2.
- Omi-X marcado con 125I demostró alta especificidad para ACE2 y retención en imágenes SPECT de ratones K18-hACE2.
- 68Ga-DOTA-Omi-X permitió la obtención de imágenes PET dirigidas a ACE2 con éxito, aplicable a enfermedades relacionadas con RAAS como la hipertrofia cardíaca.
Conclusiones:
- El péptido Omi-X sirve como una herramienta eficaz para la visualización y el mapeo no invasivos de ACE2.
- Este enfoque proporciona un paradigma para el desarrollo de terapias dirigidas aprovechando la adaptación viral-huésped.
- Los trazadores de imágenes desarrollados ofrecen herramientas valiosas para investigar la fisiopatología de RAAS y el diagnóstico de precisión.
![Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55537.jpg&w=3840&q=50)
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