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Chirality02:25

Chirality

29.5K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
29.5K
Chirality in Nature02:30

Chirality in Nature

17.2K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
17.2K
Switching of BJT01:22

Switching of BJT

857
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
857
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

7.0K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
7.0K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

15.0K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
15.0K
Secondary Motives: Power Motivation and Achievement Motivation01:27

Secondary Motives: Power Motivation and Achievement Motivation

558
Power motivation and achievement motivation are two essential social motives identified by psychologist David McClelland. These motives influence behavior in various personal and professional contexts, shaping how individuals interact with others and pursue their goals.
Power motivation is characterized by the desire to influence, control, or have an impact on others. It is shaped by an individual's experiences, social environment, and cultural context. People with high power motivation are...
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Updated: Jan 31, 2026

Synthesis and Characterization of Supramolecular Colloids
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Interruptor Quiral Supramolecular Responsivo a la Temperatura Logrado por Confinamiento Macrocyclic

Xuan Zhao1, Shuangqi Song1, Hengzhi Zhang1

  • 1College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China.

JACS Au
|January 30, 2026
PubMed
Resumen

La hidroxipropil-β/γ-ciclodextrina (HPβ/γCD) y la cucurbit[8]-urilo (CB[8]) crean nanoagregados sintonizables con pirina modificada con dipéptido de fenilalanina (PFF). Estos sistemas supramoleculares exhiben transmisión quiral y conmutación controlada por temperatura para aplicaciones en puertas lógicas y cifrado.

Palabras clave:
transmisión quiralconfinamiento macrocyclicinterruptores quirales supramolecularesresponsividad térmicamorfologías sintonizables

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Área de la Ciencia:

  • Química Supramolecular
  • Ciencia de Materiales
  • Materiales Quiroópticos

Sus antecedentes:

  • La complejación huésped-invitado es crucial para el diseño de materiales supramoleculares funcionales.
  • El reconocimiento y la transmisión quiral son desafíos clave en el desarrollo de sistemas moleculares avanzados.
  • El control de la morfología y las propiedades de los nanoagregados es esencial para aplicaciones novedosas.

Objetivo del estudio:

  • Construir nanoagregados supramoleculares sintonizables utilizando ciclodextrinas y cucurbiturilos.
  • Investigar la transmisión quiral del dipéptido de fenilalanina a la moiety de pirina.
  • Desarrollar interruptores quirales supramoleculares controlados por temperatura para aplicaciones avanzadas.

Principales métodos:

  • Complejación huésped-invitado de pirina modificada con dipéptido de fenilalanina (PFF) con hidroxipropil-β/γ-ciclodextrina (HPβ/γCD) y cucurbit[8]-urilo (CB[8]).
  • Caracterización morfológica de nanoagregados, incluyendo nanofibras, nanopartículas, nanotubos y nanohojas.
  • Análisis espectroscópico (fluorescencia y dicroísmo circular) para confirmar la transmisión quiral y cuantificar propiedades.
  • Cálculos de dinámica molecular y teoría de funcionales de densidad para dilucidar mecanismos de complejación.
  • Evaluación de la responsividad térmica y aplicación en puertas lógicas quirales y cifrado.

Principales resultados:

  • HPβ/γCD y CB[8] formaron nanoagregados sintonizables con PFF, exhibiendo transformaciones topológicas.
  • Se logró una transmisión quiral eficiente del dipéptido de fenilalanina a la pirina, lo que condujo a señales distintas de dicroísmo circular.
  • HPγCD mostró fluorescencia mejorada y propiedades de CD en comparación con HPβCD debido a la doble encapsulación de PFF.
  • CB[8] demostró una mayor afinidad de unión y un pico de CD positivo significativo.
  • Los interruptores quirales supramoleculares mostraron responsividad térmica reversible (20-75 °C) y se aplicaron con éxito en puertas lógicas quirales y cifrado dependiente de la polarización.

Conclusiones:

  • HPγCD y CB[8] son huéspedes eficaces para la construcción de interruptores quirales supramoleculares basados en PFF.
  • Los sistemas desarrollados exhiben morfología sintonizable, transmisión quiroóptica eficiente y responsividad térmica.
  • Estos interruptores quirales supramoleculares prometen aplicaciones en dispositivos ópticos avanzados y seguridad de la información.