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Updated: Jan 31, 2026

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Revisión sobre la viabilidad de aptámeros en el desarrollo de aptasensores para el análisis de bioligandos de alto

Thangavel Lakshmipriya^1,2, Subash C B Gopinath^2,3,4,5, Hemavathi Krishnan²

¹Department of Community Medicine, Saveetha Medical College & Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.

Critical reviews in analytical chemistry

|January 30, 2026

Abstract:

Aptamers are in vitro or in vivo generated bio-candidates from a synthetic library using amplification and separation procedures and have delicate options to label at the ends of properly folded secondary or tertiary structures. Aptamers are used as source molecules for sensor development since they can easily conjugate with nanomaterials and report the interactive output. Various sensing systems with enhanced sensitivity have been built in the past using aptamer conjugations. Despite the fact that the techniques for aptamer immobilization vary with functionalization chemistries, the essential strategy is reporting the presence of a specific target for sensing purposes, called an 'aptasensor'. Various attempts to analyze aptamer-ligand interaction advance the gallery of aptamer-based sensors. Aptamer administration is generally being investigated as the recognition element in high-performance analysis, and has been promoted as the exemplary molecule to mimic and replace antibody-based sensing. Using existing technologies, aptasensors are proven for more sensitive clinical and serological biomarkers sensing and high-throughput analysis.

Palabras clave:

análisis de alto rendimiento aptámeros inducidos por ligandos diagnóstico médico nanomaterial marcadores serológicos

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