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1Yale New Haven Hospital-Section of Digestive Diseases, New Haven, Connecticut, USA.
The American journal of gastroenterology
|January 30, 2026
Resumen
Esta revisión sistemática y metaanálisis examinó los síntomas gastrointestinales y extradigestivos en pacientes con enfermedad celíaca durante los desafíos de gluten. Los hallazgos resaltan los diversos perfiles de síntomas experimentados, lo que ayuda a un mejor manejo y diagnóstico del paciente.
Área de la Ciencia:
- Gastroenterología
- Nutrición Clínica
- Inmunología
Sus antecedentes:
- El diagnóstico de la enfermedad celíaca a menudo implica un desafío de gluten.
- La comprensión de la presentación de los síntomas durante los desafíos es crucial para la atención al paciente.
- Se informa variabilidad en los síntomas gastrointestinales y extradigestivos.
Objetivo del estudio:
- Revisar sistemáticamente y meta-analizar los síntomas gastrointestinales y extradigestivos.
- Evaluar la ocurrencia de síntomas en pacientes con enfermedad celíaca sometidos a desafíos de gluten con dosis especificadas.
- Proporcionar una visión general completa de la manifestación de los síntomas.
Principales métodos:
- Búsqueda sistemática de literatura en las principales bases de datos.
- Inclusión de estudios que involucran desafíos de gluten con dosis especificadas en la enfermedad celíaca.
- Metaanálisis de los síntomas gastrointestinales y extradigestivos reportados.
Principales resultados:
- Se reportó una amplia gama de síntomas gastrointestinales, incluyendo hinchazón y diarrea.
- Los síntomas extradigestivos como fatiga y dolor de cabeza también fueron prevalentes.
- La gravedad y el tipo de síntoma variaron significativamente entre los participantes.
Conclusiones:
- Los desafíos de gluten provocan diversos síntomas gastrointestinales y extradigestivos en pacientes con enfermedad celíaca.
- La conciencia de estos síntomas puede mejorar la precisión diagnóstica y el apoyo al paciente.
- Se justifica una mayor investigación sobre las relaciones dosis-respuesta.
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