Video Experimental Relacionado

Updated: Jan 31, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Frecuencia Elevada de Alelos y Predominio Masculino de una Variante Común de Línea Germinal de LAG3 en el Mieloma

Katja Seipel^1,2, Alina Mena¹, Pinar Horum¹

¹Department of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.

Current issues in molecular biology

|January 30, 2026

Abstract:

The incidence of multiple myeloma is higher in males. The underlying mechanisms may be related to differences in immune system orchestration in males and females. LAG3 and CTLA4 are immune checkpoint proteins and inhibitory regulators of T cells. Here, we analyzed the prevalence of the common LAG3 gene variant rs870849 and the common CTLA4 gene variant rs231775 in myeloma patients eligible for autologous stem cell transplantation. CTLA4 rs231775 was prevalent at normal allele frequencies. In contrast, LAG3 rs870849 was prevalent at elevated allele frequencies in myeloma patients, with allele frequency 0.61 in male and 0.53 in female patients compared to 0.39 in the European population. The gene risk analysis of rs870849 indicated an odds ratio 6.8 in male and 3.6 in female patients. Moreover, treatment outcomes differed in the three genetic LAG3 subgroups with median progression-free survival of 2.6, 3.3 and 3.4 and median overall survival of 7, 15 and 18 years in the I455hom, I455Thet and T455hom subgroups, respectively. LAG3 rs870849 may affect survival and treatment outcome after autologous stem cell transplantation in myeloma patients with favorable outcomes in rs870849 carriers.

Palabras clave:

trasplante autólogo de células madre (ASCT)proteína 4 asociada a linfocitos T citotóxicos (CTLA4)riesgo genético gen 3 de activación de linfocitos (LAG3)frecuencia de alelos menores (MAF)mieloma múltiple (MM)polimorfismo de un solo nucleótido (SNP)

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