Video Experimental Relacionado

Updated: Jan 31, 2026

Automated Microbial Cultivation and Adaptive Evolution using Microbial Microdroplet Culture System MMC

Automated Microbial Cultivation and Adaptive Evolution using Microbial Microdroplet Culture System MMC

Published on: February 18, 2022

Del nacimiento hasta más allá: predicción de la incidencia y el momento de la derivación de LCR en el cierre posnatal

Katherine Daniels¹, Kelsi M Chesney², Brannan E O'Neill³

¹Princeton University, Princeton, NJ, USA.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

|January 30, 2026

Abstracto

Purpose:

Up to 87% of individuals with myelomeningocele (MMC) develop shunt-dependent hydrocephalus, and ventriculoperitoneal shunts (VPS) significantly increase lifetime morbidity. This study aimed to identify risk factors, incidence, and timing of VPS placement to improve outcomes and guide family counseling.

Methods:

A retrospective review of 125 patients who underwent postnatal MMC closure at Children's National Hospital between 1998 and 2022 was conducted. Primary outcomes were VPS placement and age at insertion. VPS and shunt-free cohorts were compared using Mann-Whitney U, Welch's t-test, and Fisher's exact test (α = 0.05). Subanalysis examined patients shunted within 2 weeks versus 2 weeks-2 months. Youden's index determined optimal cutoffs for hydrocephalus (HCP) and frontal-occipital horn ratio (FOHR).

Results:

Sixty-nine percent of MMC patients received VPS. Among shunted patients, 16% received VPS at closure, 61% within 2 weeks, and 94% within 2 months; no shunts were placed after 1 year. Mean follow-up was 10.7 years. Higher FOHR (p < 0.0001) and HCP (p = 0.01) at birth predicted VPS placement, though only FOHR predicted earlier insertion (0.55 vs 0.48; p = 0.0003). Optimal predictive thresholds were FOHR > 0.48 and HCP > 50%.

Conclusion:

In this cohort, 69% of MMC patients developed shunt-dependent hydrocephalus. Elevated FOHR at birth predicted earlier VPS placement, and FOHR > 0.48 and HCP > 50% were predictive of VPS need. These measures may aid in family counseling and early identification of patients requiring shunting.

Palabras clave:

Hidrocefalia Mielomeningocele Disrafismo espinal Derivación ventriculoperitoneal

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