Video Experimental Relacionado
Updated: Feb 2, 2026
13:42
Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Published on: January 19, 2014
14.0K
Paraneoplásica dermatomiositis con características atípicas asociadas a un neoplasma seudopapilar sólido de páncreas
N A Uribe-Ruíz1,2, D A Domínguez-Guzmán3, J C Jaramillo-Álvarez4,5
1Rheumatology Group, Department of Internal Medicine, Universidad de Antioquia, Calle 64 #51D - 154, Medellín, Colombia. nati4421@gmail.com.
Clinical rheumatology
|January 31, 2026
Resumen
La dermatomiositis (DM) puede estar relacionada con tumores pancreáticos raros, especialmente con anticuerpos anti-TIF1γ. Los signos cutáneos atípicos como el pseudoangioedema pueden indicar este síndrome paraneoplásico, mejorando tras la extirpación del tumor.
Área de la Ciencia:
- Enfermedades autoinmunes
- Oncología
- Dermatología
Sus antecedentes:
- La dermatomiositis (DM) es una miopatía inflamatoria autoinmune a menudo asociada con malignidades.
- Los tumores seudopapilares sólidos de páncreas son neoplasias raras con bajo potencial maligno.
- La asociación entre la DM y los tumores seudopapilares sólidos de páncreas es extremadamente rara.
Objetivo del estudio:
- Informar sobre un caso extremadamente raro de dermatomiositis asociada a un tumor seudopapilar sólido de páncreas.
- Destacar las manifestaciones cutáneas atípicas y los anticuerpos anti-TIF1γ como posibles indicadores de DM paraneoplásica.
- Enfatizar la importancia de investigar tumores pancreáticos raros en pacientes con DM y autoanticuerpos específicos.
Principales métodos:
- Presentación de caso de una mujer de 21 años con síntomas de DM.
- Evaluación clínica que incluye lesiones cutáneas características y atípicas.
- Pruebas de laboratorio para enzimas musculares y anticuerpos anti-TIF1γ.
- Estudios de imagen para detectar masa pancreática y confirmación histológica.
- Evaluación de la respuesta clínica tras la resección quirúrgica del tumor.
Principales resultados:
- La paciente presentó debilidad muscular proximal, disfagia y lesiones cutáneas características de DM, además de características atípicas como pseudoangioedema.
- Se observaron enzimas musculares elevadas y anticuerpos anti-TIF1γ positivos.
- Se diagnosticó y extirpó quirúrgicamente un tumor seudopapilar sólido de páncreas.
- Tras la resección, las enzimas musculares se normalizaron y las lesiones cutáneas mejoraron, aunque persistió la cuadriparesia.
Conclusiones:
- Los hallazgos cutáneos atípicos pueden indicar dermatomiositis paraneoplásica.
- La asociación de la DM con tumores seudopapilares sólidos de páncreas es excepcionalmente rara.
- Este caso subraya la necesidad de considerar tumores pancreáticos raros en pacientes con DM y anticuerpos anti-TIF1γ.
- La mejoría clínica tras la resección del tumor apoya un vínculo paraneoplásico entre la neoplasia y la DM.
Videos de Conceptos Relacionados
02:37Metallic Solids
20.6K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
02:22Structures of Solids
17.7K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.7K
01:21Antipsychotic Drugs: Typical and Atypical Agents
852
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
852
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
02:54Molecular and Ionic Solids
20.1K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K
02:26Molecular Comparison of Gases, Liquids, and Solids
55.1K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
55.1K