Video Experimental Relacionado

Updated: Feb 2, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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Published on: September 10, 2018

Diseño y optimización de microemulgel de ibuprofeno para una administración dérmica eficaz y mejorada

Amna Nosheen Jaweria¹, Sehar Khalid¹, Maiza Mubashaar¹

¹Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Pakistan journal of pharmaceutical sciences

|February 1, 2026

Abstracto

Background:

The oral administration of ibuprofen is limited due to gastrointestinal adverse effects and inadequate solubility, necessitating the development of enhanced cutaneous delivery systems.

Objectives:

The objective of this study was to create and optimize a microemulgel for ibuprofen to improve solubility, permeability and prolonged release.

Methods:

Microemulsions were prepared using phase titration utilizing Tween 80, butanol and vegetable oil, thereafter incorporating carbopol gel. Preformulation studies encompassed solubility and partition coefficient. Post-formulation characterization involved globule size, zeta potential, pH, drug content and in-vitro/ex-vivo release analyses. Compatibility was evaluated by utilizing FTIR and DSC techniques.

Results:

The improved formulation (F3) exhibited a droplet size of 117.5 nm, a zeta potential of -6.47 mV and a drug content of 82.94%. FTIR and DSC analyses validated compatibility. Ex-vivo investigations revealed improved skin permeability and drug release conformed to the Korsmeyer-Pappas model (n = 0.626), signifying non-Fickian diffusion.

Conclusion:

The formulated ibuprofen microemulgel demonstrated stability, compatibility with skin and prolonged drug release, indicating its potential as an effective option for topical NSAID administration.

Palabras clave:

Liberación controlada Ibuprofeno Microemulgel Diagrama de fases pseudoternario Permeación cutánea Sistema de administración de fármacos tópicos

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