Video Experimental Relacionado
Updated: Feb 3, 2026
11:53
Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
Published on: December 9, 2012
13.5K
PKRxiv: Un modelo de mejores prácticas para avanzar en la farmacoequidad a través del intercambio abierto de datos
Shakir Atoyebi1,2, Prajith Venkatasubramanian1,2, Abdulafeez Akinloye3,4
1Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Clinical pharmacology and therapeutics
|February 1, 2026
Resumen
PKRxiv es un nuevo repositorio que promueve el intercambio de datos farmacocinéticos utilizando los principios FAIR. Mejora la transparencia y la colaboración en el desarrollo de fármacos al hacer accesibles más de 5500 puntos de datos.
Área de la Ciencia:
- Farmacología Clínica
- Desarrollo de Fármacos
- Ciencia de Datos
Sus antecedentes:
- El desarrollo de fármacos guiado por modelos (MIDD) mejora la eficiencia de los ensayos y reduce las pruebas en animales.
- La farmacoequidad requiere un acceso equitativo a los medicamentos, los datos y el conocimiento.
- Existen desafíos en el intercambio de datos farmacocinéticos (PK).
Objetivo del estudio:
- Presentar PKRxiv, un repositorio específico de la disciplina para datos PK.
- Promover la adhesión a los principios FAIR (Findable, Accessible, Interoperable, Reusable).
- Facilitar la investigación transparente y colaborativa en farmacología clínica.
Principales métodos:
- Diseño del repositorio PKRxiv basado en los principios FAIR.
- Presentación estructurada de datos para datos PK, farmacogenéticos y de seguridad/eficacia.
- Modelos flexibles de intercambio de datos (sin restricciones, no comercial, controlado por el contribuyente) con opciones de embargo.
Principales resultados:
- Más de 5500 puntos de datos individuales de concentración-tiempo de fármacos de >900 participantes de 3 continentes disponibles en septiembre de 2025.
- Identificadores persistentes de objetos digitales (DOI) para la descubribilidad y la citación.
- Explorador de datos y tarjetas de datos para la exploración de conjuntos de datos.
Conclusiones:
- PKRxiv apoya la agrupación de datos entre estudios para avanzar en la farmacología clínica.
- Las recomendaciones incluyen obtener el consentimiento para el uso futuro de los datos y estandarizar el intercambio de datos.
- Fomenta el intercambio de datos posteriores a la aprobación por parte de la industria para fomentar la transparencia y la equidad.
Videos de Conceptos Relacionados
01:14Model Approaches for Pharmacokinetic Data: Compartment Models
559
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Two primary types of compartment models are recognized: mammillary and catenary. The more...
559
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
276
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
276
01:06Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
249
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
249
01:14Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches
539
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
539
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
330
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
330
01:12Analysis of Population Pharmacokinetic Data
753
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
753