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Diferencias en Anomalías Congénitas en la Concepción No Asistida versus Fertilización In Vitro en Embarazos Gemelares

Hannah S Foster¹, Meaghan G McCabe¹, Nathaniel Koelper¹

¹University of Pennsylvania Department of Obstetrics and Gynecology, Philadelphia PA.

Fertility and sterility

|February 1, 2026

Abstracto

Objective:

The aim of this study was to evaluate the incidence of congenital anomalies in dichorionic-diamniotic twins conceived with in-vitro fertilization (IVF) versus unassisted conception pregnancies in a large geographically diverse population.

Design:

This is a secondary analysis of data from a retrospective cohort study of twin pregnancies seen at 17 centers between 12/2011-2/2020.

Subjects:

This study included dichorionic-diamniotic twins conceived unassisted, or by in-vitro fertilization.

Exposure:

The exposure group is dichorionic-diamniotic twins conceived with IVF.

Main Outcome Measure:

The primary outcome was presence of a congenital anomaly. Neonates with an abnormal newborn exam were evaluated for having a major or minor congenital anomaly and the major anomalies were further classified by organ system (cardiac, renal/genitourinary, gastrointestinal, and musculoskeletal).

Results:

Of the 968 dichorionic-diamniotic twin pregnancies included, 521 (53.8%) were conceived with IVF and 447 (46.2%) were conceived unassisted. Congenital anomalies were found in 70 pregnancies (7.23%). Of those, 37 were found in pregnancies conceived by IVF (52.9%) versus 33 unassisted conception pregnancies (47.1) (p=0.87). There were no significant differences between IVF and unassisted conception pregnancies for major anomalies (p=0.65) or minor anomalies (p=0.94).

Conclusion:

In this large cohort of twin pregnancies, there is no significant difference in the incidence of anomalies for dichorionic-diamniotic twin pregnancies conceived by IVF versus unassisted conception pregnancies.

Palabras clave:

FIV corionicidad anomalías congénitas dicoriónico-diamniótico embarazo gemelos

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