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Updated: Feb 4, 2026

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
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¿Cómo afecta la terapia de plasma a la expresión del VDR en ancianos?

Ender Deniz Asmaz1, Hikmet Taner Teker2, Taha Ceylani3

  • 1Department of Histology and Embryology, Ankara Medipol University Faculty of Medicine, Ankara, Türkiye.

Journal of clinical practice and research
|February 2, 2026
PubMed
Resumen
Este resumen es generado por máquina.

La terapia de plasma joven mejoró la digestión y aumentó la expresión del receptor de vitamina D (VDR) en ratas de edad avanzada. Esto apoya la regeneración de órganos y la renovación hormonal, contrarrestando el declive relacionado con la edad.

Palabras clave:
Histomorfologíainmunohistoquímicayeyunoterapia de plasmareceptor de vitamina D

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Área de la Ciencia:

  • Gerontología
  • Medicina Regenerativa
  • Gastroenterología

Sus antecedentes:

  • El plasma joven contiene factores rejuvenecedores que disminuyen con la edad, lo que afecta la regeneración de órganos y la función hormonal.
  • La expresión del receptor de vitamina D (VDR) disminuye con el envejecimiento, lo que afecta potencialmente los procesos fisiológicos.
  • La terapia de plasma se explora como un método para restaurar factores juveniles y contrarrestar los efectos del envejecimiento.

Objetivo del estudio:

  • Investigar los efectos de la terapia de plasma joven en la histomorfología y los niveles del receptor de vitamina D (VDR) en ratas de edad avanzada.
  • Evaluar el potencial de la terapia de plasma para la regeneración de órganos y el soporte hormonal.

Principales métodos:

  • Se administró plasma combinado de ratas jóvenes a ratas Wistar de edad avanzada.
  • Se midieron los parámetros histomorfológicos (altura de la vellosidad, grosor de la mucosa, profundidad de la cripta, área de superficie) del yeyuno.
  • Se cuantificó la expresión del receptor de vitamina D (VDR) mediante inmunohistoquímica.

Principales resultados:

  • La terapia de plasma aumentó la profundidad de las criptas yeyunales en comparación con los controles jóvenes.
  • Tanto la terapia de plasma joven como los controles jóvenes mostraron mejoras en los parámetros histomorfológicos y de VDR en comparación con los controles de edad avanzada.
  • No se observaron diferencias significativas en la altura de las vellosidades, el grosor de la mucosa o el área de superficie entre los grupos tratados con plasma joven y los controles jóvenes.

Conclusiones:

  • La terapia de plasma joven mejora los parámetros que apoyan la digestión y aumenta la expresión del VDR en ratas de edad avanzada.
  • Esto sugiere una influencia beneficiosa de la terapia de plasma para contrarrestar el declive relacionado con la edad.