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Colorimetría ultrarrápida nanoplasmónica en microfluídica para pruebas de susceptibilidad antimicrobiana directamente

Mahsa Jalali^1,2, Tamer AbdElFatah¹, Carolina Del Real Mata¹

¹Department of Bioengineering, McGill University, Montreal, Quebec, Canada.

Nature nanotechnology

|February 2, 2026

Resumen

Una nueva plataforma QolorPhAST utiliza colorimetría nanoplasmónica para pruebas rápidas de susceptibilidad antimicrobiana (AST). Esta tecnología acelera significativamente la identificación bacteriana y el perfilado de resistencia a los antibióticos, de días a minutos.

Área de la Ciencia:

Microbiología
Nanotecnología
Diagnóstico Médico

Sus antecedentes:

La resistencia antimicrobiana (AMR) requiere diagnósticos rápidos para un tratamiento eficaz.
Las pruebas estándar de susceptibilidad antimicrobiana (AST) consumen mucho tiempo, lo que retrasa las decisiones clínicas críticas.

Objetivo del estudio:

Presentar QolorPhAST, una plataforma novedosa para la identificación bacteriana rápida y AST.
Demostrar la capacidad de QolorPhAST para reducir significativamente los tiempos de respuesta para el perfilado de susceptibilidad.

Principales métodos:

Desarrollo de una plataforma automatizada modular que utiliza colorimetría nanoplasmónica en microfluídica.
Identificación bacteriana paralela y perfilado fenotípico de AST.
Validación en 10 especies bacterianas y 34 cepas con diferentes concentraciones de antibióticos.

Principales resultados:

QolorPhAST logró una mejora de ocho veces en la rapidez de detección en comparación con los métodos estándar.
Redujo el tiempo de perfilado de la susceptibilidad a los medicamentos de días a minutos, evitando los cultivos nocturnos.
En un estudio clínico, logró una precisión del 100% en la identificación de especies y altas tasas de concordancia (91,81% categórica, 86,4% esencial) en 36 minutos.

Conclusiones:

QolorPhAST ofrece una solución transformadora para AST rápida, abordando la crisis de AMR.
La plataforma demuestra facilidad de uso y rentabilidad para aplicaciones clínicas.
Permite decisiones de tratamiento antibiótico oportunas y precisas a través de la identificación acelerada de patógenos y el perfilado de resistencia.

Palabras clave:

microfluídica nanoplasmónica pruebas de susceptibilidad antimicrobiana identificación bacteriana resistencia a los antibióticos diagnóstico rápido crisis de resistencia a los antimicrobianos tratamiento antibiótico oportuno

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