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Transcriptoma gonadal específico de sexo durante el desarrollo temprano del esturión siberiano
André Lasalle Gerla1, Germán Benech-Correa1, Christophe Klopp2
1Laboratorio de Fisiología de la Reproducción y Ecología de Peces, Instituto de Biología, Facultad de Ciencias, Universidad de la República Oriental del Uruguay, Iguá, Montevideo, 4225, 11400, Uruguay.
Biology of sex differences
|February 3, 2026
Resumen
La diferenciación sexual temprana en el esturión siberiano involucra vías de estrógenos y genes novedosos. Este estudio identifica factores moleculares clave para el desarrollo tanto femenino como masculino en esta especie de pez basal.
Área de la Ciencia:
- Aquatic biology; Genetics; Molecular biology
Sus antecedentes:
- Sex determination and differentiation are complex and poorly understood in basal non-teleost fishes like Siberian sturgeon.
- Genetic sexing of Siberian sturgeon allows for the study of undifferentiated individuals to identify early sexual differentiation factors.
Objetivo del estudio:
- To identify molecular factors involved in early sexual differentiation in Siberian sturgeon.
- To investigate sex-biased gene expression in undifferentiated gonads of Siberian sturgeon.
Principales métodos:
- Genetic sexing of twelve 2.5-month-old Siberian sturgeon (six males, six females).
- RNA extraction from gonad samples and transcriptome assembly using a reference dataset.
- Bioinformatic analyses including differential gene expression, Gene Ontology (GO) enrichment, and coding/non-coding sequence classification.
Principales resultados:
- Identified female-biased genes including estrogen production genes (hsd17b1, cyp19a1, foxl2) and immediate early response genes (jun-b, c-fos, egr1).
- Discovered novel genes potentially linked to estradiol and female differentiation, such as di-ras2, ier2, and aanat.
- Found male-biased upregulation of tbx1 and novel candidates (plin1, nrxn3, chs2, mmp9), with no identified sex-biased androgen production genes.
Conclusiones:
- Sex-specific gonadal differences are evident in Siberian sturgeon by 2.5 months of age.
- The estrogen response pathway and immediate early response genes are crucial for female differentiation.
- Male differentiation involves tbx1 and new candidate genes, independent of sex-biased androgen production.
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