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Interacciones proteína-ADN en enfermedades y descubrimiento de fármacos

Richa Mishra¹, Shandar Ahmad¹

¹School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India. shandar@jnu.ac.in.

Chemical communications (Cambridge, England)

|February 3, 2026

Resumen

Las interacciones proteína-ADN (PDIs) son cruciales en la salud y la enfermedad. A pesar de los desafíos, las PDIs están emergiendo como dianas farmacológicas viables, con muchos candidatos en desarrollo clínico.

Área de la Ciencia:

Biología Molecular
Genética
Farmacología

Sus antecedentes:

Las interacciones proteína-ADN (PDI) son procesos biológicos esenciales fundamentales para todos los organismos.
La desregulación de las PDI se implica en el inicio, progresión y gravedad de las enfermedades.
La orientación de las PDI para la intervención terapéutica presenta desafíos debido a factores como las interacciones de la columna vertebral del ADN.

Objetivo del estudio:

Revisar el papel de las PDI en la transcripción humana, la replicación y reparación, y la organización del genoma.
Destacar las PDI como dianas terapéuticas viables en diversas enfermedades.
Examinar los esfuerzos de descubrimiento de fármacos y los métodos computacionales, incluida la IA, para dirigirse a las PDI.

Principales métodos:

Revisión de la literatura de PDI en biología humana y enfermedad.
Compilación de PDI dirigidas por fármacos en ensayos clínicos o aprobados.
Revisión de enfoques computacionales y basados en IA para el descubrimiento de fármacos de PDI.

Principales resultados:

La desregulación de las PDI en la transcripción, replicación y reparación, y la organización del genoma está relacionada con enfermedades.
Un número creciente de PDI y fármacos asociados han llegado a ensayos clínicos o etapas de aprobación.
Los métodos computacionales, en particular la IA, están acelerando el descubrimiento de fármacos de PDI.

Conclusiones:

Las PDI, a pesar de los desafíos históricos, son cada vez más reconocidas como dianas tratables.
La revisión demuestra el creciente potencial y éxito de la orientación de las PDI para beneficio terapéutico.
El momento es oportuno para aprovechar las PDI como dianas terapéuticas efectivas, respaldadas por metodologías avanzadas.

Palabras clave:

interacciones proteína-ADN dianas farmacológicas descubrimiento de fármacos terapéutica biología molecular genética farmacología IA

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