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Valor del Seguimiento Óptimo en Pacientes con Embolia Pulmonar (SOEP): Protocolo de Estudio para un Estudio

Mingjie Liu¹, Chunyi Lv¹, Xianming Qiu²

¹Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

|February 3, 2026

Abstract:

BackgroundRecent advances in the diagnosis and treatment of pulmonary thromboembolism (PTE) have significantly improved survival rates. This progress has shifted greater attention to long-term prognosis, highlighting the need for holistic management that integrates acute care, systematic follow-up, and continuous monitoring.MethodsThe Optimal Follow-Up in Pulmonary Embolism (OFUPE) is a prospective randomized study comparing two follow-up strategies in acute PTE patients: (1) the optimal follow-up strategy, which comprises a systematic protocol incorporating evidence-based education, individualized care planning, and telemedicine support; and (2) the routine follow-up strategy, consisting of standard monitoring. Eligible patients with acute PTE are randomly assigned in a 1:1 ratio to each group. Primary endpoints include all-cause mortality and adverse events.DiscussionThe OFUPE study examines the role of holistic management in PTE and proposes a systematic framework for post-PTE care.Trial registration Chinese Clinical Trial Registry ChiCTR2200064675.

Palabras clave:

estudios de seguimiento pronóstico estudios prospectivos embolia pulmonar

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