Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.2K
Overview
80.2K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

656
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
656
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

885
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
885

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Operative Duration as an Independent Risk Factor for Lower-Extremity Deep Vein Thrombosis Following Shoulder Arthroscopy: A Prospective Cohort Study With Systematic Ultrasonographic Screening.

Orthopaedic journal of sports medicine·2026
Same author

Zinc-polydopamine nanozyme promotes mitochondrial biogenesis and alleviates inflammation and muscle atrophy during the perioperative period of surgery.

Journal of materials science. Materials in medicine·2026
Same author

Global Research Trends and Thematic Evolution in Robotic Surgery for Obstructive Sleep Apnoea: A Bibliometric and Visualisation Study.

Journal of robotic surgery·2026
Same author

Theoretical design of diatomic catalysts for selective hydrodeoxygenation of furfural to 2-methylfuran.

Physical chemistry chemical physics : PCCP·2026
Same author

CoFe alloy nanoparticles embedded in carbon nanofibers for efficient synthesis of ammonia from nitrate reduction.

Chemical communications (Cambridge, England)·2026
Same author

Effects of microhabitat construction on water-ecosystem coupling in Urban Rivers: integrated assessment of water quality and biodiversity responses in Beijing, China.

Water science and technology : a journal of the International Association on Water Pollution Research·2026

Video Experimental Relacionado

Updated: Feb 5, 2026

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

34.2K

Exploración de la patogénesis de los enterovirus y el potencial de la terapia contra el cáncer a través de la

Shijin Wang1,2, Qing Yu2,3, Junfeng Zhou4

  • 1Cancer Center, The First Hospital of Jilin University, Changchun 130021 China.

Biosafety and health
|February 4, 2026
PubMed
Resumen

Los enterovirus oncolíticos (EV) muestran promesa para el tratamiento del cáncer debido a su especificidad tumoral. Los avances en genética inversa mejoran la comprensión de la infección por EV y ayudan al desarrollo de nuevas inmunoterapias.

Palabras clave:
Enterovirus (EV)Virus oncolítico (OV)PatogénesisGenética inversaInmunidad tumoral

Más Videos Relacionados

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
13:48

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

17.2K
Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K

Videos de Experimentos Relacionados

Last Updated: Feb 5, 2026

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

34.2K
Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
13:48

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

17.2K
Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K

Área de la Ciencia:

  • Virología
  • Oncología
  • Biología Molecular

Sus antecedentes:

  • Los virus oncolíticos están emergiendo como potentes agentes anticancerígenos.
  • Los enterovirus (EV) exhiben un tropismo específico por las células tumorales, lo que los convierte en candidatos atractivos para la oncolisis.
  • La genética inversa se ha convertido en una herramienta poderosa para estudiar los mecanismos virales y desarrollar aplicaciones terapéuticas.

Objetivo del estudio:

  • Revisar el progreso y las aplicaciones clínicas potenciales de la genética inversa en el desarrollo de enterovirus oncolíticos.
  • Explorar las características de los EV y el papel de la genética inversa en la comprensión de sus mecanismos de infección y potencial oncolítico.
  • Destacar enterovirus específicos con roles oncolíticos y su importancia en la inmunoterapia contra el cáncer.

Principales métodos:

  • Revisión de la literatura científica sobre enterovirus oncolíticos y genética inversa.
  • Análisis de estudios que investigan el tropismo y la patogénesis de los enterovirus.
  • Discusión de serotipos específicos de enterovirus con actividad oncolítica demostrada.

Principales resultados:

  • La genética inversa ha avanzado significativamente la comprensión de los mecanismos de infección y la patogénesis de los enterovirus.
  • Ciertos enterovirus, incluidos EV-A71, CV-B3, Echo-7, CV-A21 y poliovirus, han demostrado potencial oncolítico.
  • La aplicación de la genética inversa facilita el desarrollo de enterovirus oncolíticos modificados para la terapia contra el cáncer.

Conclusiones:

  • Los enterovirus oncolíticos modificados mediante genética inversa ofrecen una vía prometedora para el tratamiento del cáncer.
  • El tropismo tumoral específico de ciertos EV mejora su potencial como agentes oncolíticos dirigidos.
  • La investigación adicional y la traslación clínica de los EV oncolíticos prometen mucho para la inmunoterapia contra el cáncer.