Video Experimental Relacionado
Updated: Feb 5, 2026
08:31
Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
11.0K
Una reacción inesperada a dupilumab
Gabriela E Beraja1, Connor J Stonesifer1, Danyelle M Dawes1
1Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, USA.
Cureus
|February 4, 2026
Resumen
La sarna costrosa (SC) puede ocurrir en pacientes tratados con dupilumab. Este caso destaca la necesidad de un tratamiento prolongado con ivermectina para la resolución completa en tales casos.
Área de la Ciencia:
- Dermatología
- Inmunología
- Parasitología
Sus antecedentes:
- La sarna costrosa (SC) es una forma grave y contagiosa de sarna caracterizada por la proliferación extensa de ácaros en la piel.
- El diagnóstico de SC puede ser un desafío debido a su similitud con los trastornos hiperqueratósicos.
- Las terapias biológicas se han asociado con la SC, y algunos casos se resuelven con ivermectina.
Objetivo del estudio:
- Informar un caso de sarna costrosa en un paciente en tratamiento con dupilumab.
- Investigar el papel potencial de dupilumab en el desarrollo de SC.
- Destacar el curso del tratamiento y los resultados de la SC en pacientes con dupilumab.
Principales métodos:
- Informe de caso de un paciente con SC mientras recibía dupilumab.
- Revisión de la literatura previa sobre SC y terapias biológicas.
- Análisis de la respuesta al tratamiento con un régimen prolongado de ivermectina.
Principales resultados:
- El paciente con SC en dupilumab requirió un régimen de ivermectina extendido de siete días para la resolución completa.
- Esto contrasta con informes anteriores de resolución rápida en casos similares.
- La supresión de Th2 por dupilumab puede contribuir a la proliferación incontrolada de ácaros.
Conclusiones:
- La terapia con dupilumab puede aumentar el riesgo de infecciones escabióticas persistentes.
- Puede ser necesario un tratamiento prolongado contra la sarna para la SC en pacientes con dupilumab.
- Se necesita más investigación sobre los mecanismos inmunológicos de la SC en pacientes inmunocomprometidos.
Videos de Conceptos Relacionados
03:06Reaction Mechanisms
30.9K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.9K
02:53Determining Order of Reaction
62.1K
Rate laws describe the relationship between the rate of a chemical reaction and the concentration of its reactants. In a rate law, the rate constant k and the reaction orders are determined experimentally by observing how the rate of reaction changes as the concentrations of the reactants are changed. A common experimental approach to the determination of rate laws is the method of initial rates. This method involves measuring reaction rates for multiple experimental trials carried out using...
62.1K
02:22Reaction Yield
59.9K
The theoretical yield of a reaction is the amount of product estimated to form based on the stoichiometry of the balanced chemical equation. The theoretical yield assumes the complete conversion of the limiting reactant into the desired product. The amount of product that is obtained by performing the reaction is called the actual yield, and it may be less than or (very rarely) equal to the theoretical yield.
59.9K
02:53Reaction Rate
64.0K
The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
64.0K
02:35Reaction Quotient
53.1K
The status of a reversible reaction is conveniently assessed by evaluating its reaction quotient (Q). For a reversible reaction described by m A + n B ⇌ x C + y D, the reaction quotient is derived directly from the stoichiometry of the balanced equation as
53.1K
02:42Half-life of a Reaction
39.1K
The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
39.1K