Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Pain01:20

Pain

1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

2.6K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
2.6K
Associative Learning01:27

Associative Learning

1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Purposive Learning01:22

Purposive Learning

512
E. C. Tolman emphasized the purposiveness of behavior — the idea that much of our behavior is goal-directed. For instance, employees who aim for a promotion work diligently to meet their targets. Tolman argued that when classical conditioning and operant conditioning occur, the organism acquires certain expectations. In classical conditioning, a child might fear a dog because they expect it to bite. In operant conditioning, a person might consistently work overtime because they expect a...
512
Observational Learning01:12

Observational Learning

992
Albert Bandura's observational learning, also known as imitation or modeling, occurs when a person observes and imitates another's behavior. It is a quicker process than operant conditioning. A well-known example is the Bobo doll study, where children who saw an adult acting aggressively towards the doll were more likely to act aggressively when left alone, compared to those who observed a nonaggressive adult. Many psychologists view observational learning as a form of latent learning...
992
Learning Disabilities01:25

Learning Disabilities

618
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
618

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Using honeybees for national scale long-term eDNA biomonitoring.

PloS one·2026
Same author

Transcriptomic insights into the co-occurring psychological symptoms and cardiovascular risks among military service members and veterans with mild traumatic brain injury: A LIMBIC-CENC study.

Brain, behavior, & immunity - health·2026
Same author

Species-Level Characterization of the Nasal Microbiome in Various Disease States Utilizing Third-Generation Sequencing.

International forum of allergy & rhinology·2026
Same author

Association of Marshall CT Scores with GFAP, UCH-L1, Tau, NfL, and p-Tau231 After Traumatic Brain Injury.

International journal of molecular sciences·2025
Same author

Editorial: Integrated diagnostics and biomarker discovery in endocrinology and biomedical sciences, volume II.

Frontiers in endocrinology·2025
Same author

Thoracic Outlet Syndrome After Implant-based Breast Reconstruction.

Plastic surgery (Oakville, Ont.)·2025
Same journal

Voluntary wheel running decreases intraepidermal nerve fibers in healthy mice.

Pain reports·2026
Same journal

Pirt promotes substance P release in cancer-induced bone pain.

Pain reports·2026
Same journal

Pain, function, and acute neuropathic pain up to one month after surgery: a registry-based analysis.

Pain reports·2026
Same journal

Perioperative pregabalin does not alter behavioural or diffuse noxious inhibitory control responses in 2 rat models of chronic pain.

Pain reports·2026
Same journal

Suppression of visceral nociception by C-fiber transmission block using temporal interference sinusoidal stimulation.

Pain reports·2026
Same journal

Daily perceived change among patients with chronic pain: influence of sociodemographic, clinical, and psychological characteristics.

Pain reports·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Feb 5, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

21.7K

Transcriptómica del dolor humano: lecciones aprendidas hasta ahora

Bradford Hall1, Lauren Cook1, Sijung Yun2

  • 1Functional Genomics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Pain reports
|February 4, 2026
PubMed
Resumen
Este resumen es generado por máquina.

El dolor crónico afecta a muchos adultos, lo que requiere una comprensión más profunda de las vías del dolor humano. Los estudios transcriptómicos de los ganglios de la raíz dorsal revelan información, pero resaltan la necesidad de investigación multiómica para encontrar nuevos tratamientos para el dolor.

Palabras clave:
dolor cróniconeuropatía diabéticaganglios de la raíz dorsalmultiómicaartritis reumatoidetranscriptómica

Más Videos Relacionados

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.5K
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
10:32

Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl

Published on: August 14, 2013

8.3K

Videos de Experimentos Relacionados

Last Updated: Feb 5, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

21.7K
Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.5K
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
10:32

Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl

Published on: August 14, 2013

8.3K

Área de la Ciencia:

  • Neurociencia; Genómica; Investigación del dolor

Sus antecedentes:

  • El dolor crónico es un problema de salud pública importante, que supera la prevalencia de diabetes, depresión e hipertensión en adultos de EE. UU.
  • Los modelos animales existentes tienen limitaciones en la traducción de hallazgos a la terapéutica humana, lo que crea una necesidad urgente de investigación del dolor basada en humanos.
  • La comprensión de las vías nociceptivas humanas es crucial para el desarrollo de analgésicos eficaces y la mejora de la traducción terapéutica.

Objetivo del estudio:

  • Estudiar sistemáticamente las vías nociceptivas humanas utilizando datos integrados moleculares, celulares y a nivel de sistemas.
  • Identificar objetivos clínicamente relevantes para la terapéutica del dolor mediante el análisis de la fisiopatología del dolor crónico humano.
  • Aprovechar los avances en la secuenciación de próxima generación y los tejidos derivados de pacientes para la investigación del dolor.

Principales métodos:

  • Examinar los cambios transcriptómicos en los ganglios de la raíz dorsal (DRG) de personas con dolor crónico.
  • Analizar datos de tecnologías de secuenciación de próxima generación.
  • Integrar datos moleculares, celulares y a nivel de sistemas para un estudio integral de las vías nociceptivas.

Principales resultados:

  • Los estudios transcriptómicos iniciales de los DRG han investigado afecciones como el dolor radicular/neuropático, la neuropatía diabética y la artritis reumatoide.
  • Estos estudios han comenzado a revelar alteraciones transcriptómicas asociadas con estados de dolor crónico.
  • Los hallazgos subrayan la necesidad de enfoques multiómicos para dilucidar completamente los procesos nociceptivos humanos.

Conclusiones:

  • El análisis transcriptómico de los DRG humanos proporciona información valiosa sobre los mecanismos del dolor crónico.
  • La investigación adicional impulsada por la multiómica es esencial para una comprensión completa y una focalización eficaz de los procesos nociceptivos humanos.
  • Este enfoque es fundamental para avanzar en el éxito traslacional en la terapéutica del dolor.