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Películas delgadas de alcohol polivinílico/óxido de grafeno cargadas con cefalexina como apósito antibacteriano para
Soroush Barkhordari1, Soroush Yousefi2, Safa Momeni Badeleh3
1Department of Organic Chemistry, Faculty Chemistry, Alzahra University Tehran 19938-93973 Iran br_soroush@yahoo.com +989121300969.
RSC advances
|February 4, 2026
Resumen
Se desarrollaron películas delgadas biodegradables de alcohol polivinílico/óxido de grafeno para la administración tópica de cefalexina. Estas películas muestran una actividad antibacteriana prometedora y una liberación controlada del fármaco, lo que indica un potencial para aplicaciones en la curación de heridas.
Área de la Ciencia:
- Ciencia de Materiales
- Ingeniería Biomédica
- Sistemas de Liberación de Fármacos
Sus antecedentes:
- Los sistemas de administración tópica de fármacos requieren materiales con propiedades de liberación controlada.
- Los polímeros biodegradables ofrecen ventajas para las aplicaciones de curación de heridas.
- La incorporación de óxido de grafeno puede mejorar las propiedades del material.
Objetivo del estudio:
- Desarrollar y caracterizar películas delgadas biodegradables de alcohol polivinílico/óxido de grafeno para la administración tópica de cefalexina.
- Investigar la carga del fármaco, la cinética de liberación y la eficacia antibacteriana de las películas desarrolladas.
- Evaluar la citocompatibilidad y las propiedades físicas del sistema de administración de fármacos en película delgada.
Principales métodos:
- Método de moldeo por solvente para la fabricación de películas delgadas.
- FTIR, XRD, SEM y EDX para la caracterización del material.
- Estudios de ángulo de contacto con agua, degradación, hinchamiento y liberación de fármacos en PBS.
Principales resultados:
- Se fabricaron películas delgadas uniformes y lisas con carga y dispersión exitosas de cefalexina.
- El óxido de grafeno mejoró la estabilidad térmica y la hidrofobicidad; la cefalexina disminuyó la estabilidad térmica.
- Se observaron degradación e hinchamiento dependientes del pH, con un perfil de liberación de cefalexina en dos etapas.
Conclusiones:
- Las películas delgadas de alcohol polivinílico/óxido de grafeno desarrolladas son adecuadas para la administración tópica de cefalexina.
- Las películas exhiben una potente actividad antibacteriana contra bacterias Gram-positivas y Gram-negativas.
- El material demuestra una buena citocompatibilidad a concentraciones relevantes, lo que sugiere un potencial terapéutico.
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