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Mutaciones genéticas funcionales en LTF influyen en su concentración en la leche

Xiuge Wang^1,2,3,4, Menglei Zhang^1,2,3,4, Yaran Zhang^1,2,3

¹Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, P. R. China.

The Journal of dairy research

|February 4, 2026

Resumen

Se identificaron dos polimorfismos de un solo nucleótido (SNP) vinculados en el promotor de la lactotransferrina bovina. Estos SNP impactan significativamente la expresión de la lactotransferrina, ofreciendo potencial para la mejora genética en vacas lecheras.

Área de la Ciencia:

Genética Animal
Biología Molecular
Ciencias Lácteas

Sus antecedentes:

La lactotransferrina (LTF) es una glicoproteína crucial en las vacas lecheras, vital para la defensa inmunitaria, el crecimiento y la calidad de la leche.
La expresión génica está regulada por mecanismos complejos, y las variaciones en la región promotora influyen significativamente en los niveles de expresión.

Objetivo del estudio:

Identificar variaciones en la secuencia de la región promotora de la lactotransferrina bovina.
Investigar la asociación de las variaciones identificadas con el contenido de lactotransferrina en vacas Holstein.
Determinar el impacto funcional de estas variaciones en la actividad del promotor de la lactotransferrina y la expresión génica.

Principales métodos:

Análisis de secuenciación de la región promotora de la lactotransferrina bovina.
Identificación y genotipado de polimorfismos de un solo nucleótido (SNP).
Análisis de asociación entre SNP y contenido de lactotransferrina en 301 vacas Holstein.
Ensayos de genes reporteros utilizando fragmentos del promotor con diferentes genotipos de lactotransferrina.

Principales resultados:

Se identificaron dos sitios de polimorfismo de un solo nucleótido (SNP) vinculados en el promotor de la lactotransferrina bovina.
Se encontró una asociación significativa entre estos SNP y el contenido de lactotransferrina en la población de vacas Holstein estudiada.
Se demostró que los SNP identificados influyen significativamente en la actividad del promotor de la lactotransferrina y, en consecuencia, en la expresión de la lactotransferrina.

Conclusiones:

Los SNP identificados son reguladores clave de la expresión de la lactotransferrina bovina.
Estos hallazgos mejoran la comprensión de los mecanismos de regulación del gen de la lactotransferrina.
Los SNP descubiertos proporcionan una base para las estrategias de selección genética para mejorar el contenido de lactotransferrina y el rendimiento de las vacas lecheras.

Palabras clave:

vacas Holstein lactotransferrina promotor polimorfismo de un solo nucleótido

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