Segmentación multiclase de la red de Willis consciente de la topología a partir de imágenes MRA y CTA

The Circle of Willis (CoW) is an essential network of arteries that ensures blood flow throughout the brain. From a clinical perspective, evaluating the vessels of the CoW is highly relevant as its angioarchitecture and variants are important biomarkers of neurovascular pathologies. However, achieving a topologically accurate segmentation of these vessels remains challenging due to their anatomical complexity. In this work, we propose a pipeline for the multiclass segmentation of the CoW vessels (13 possible classes), focusing on achieving both topology correctness and segmentation accuracy in magnetic resonance angiography (MRA) and computed tomography angiography (CTA) imaging techniques. We propose a deep learning framework based on the nnUNet model, together with a post-processing block that requires no additional training and that is adapted to the specific multiclass CoW segmentation task. We train and validate our framework using the publicly available TopCoW 2024 dataset (MRA and CTA) and evaluate it on the hidden test set (through an online system) and on an independent subset from the CROWN 2023 challenge dataset (MRA). The obtained results demonstrate the positive impact of our approach, achieving an average Dice (centerline Dice) scores of 0.90 (0.99) for MRA and 0.88 (0.99) for CTA on the in-domain test set, and 0.81 (0.97) on the out-of-domain test set for MRA. These high performances align with state-of-the-art methods, and rank among the top in the TopCoW 2024 challenge. The approach is publicly available for the research community at https://github.com/NIC-VICOROB/CoW-multiclass-segmentation-TopCoW24.