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Updated: Feb 6, 2026

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

Published on: June 4, 2021

Ajuste automático de frecuencia para espectroscopia RMN de banda ancha: una solución basada en LabVIEW

Yanan Li¹, Hadrien Mayaffre², Florian Bärtl³

¹Laboratoire National des Champs Magnétiques Intenses, LNCMI-CNRS (UPR3228), EMFL, Univ. Grenoble Alpes, Univ. Toulouse, INSA-T, 38042, Grenoble Cedex 9, France; College of Electronic and Information Engineering, Liaoning Technical University, 125105, Huludao, Liaoning, China.

Journal of magnetic resonance (San Diego, Calif. : 1997)

|February 4, 2026

Abstract:

This work introduces an automated frequency-tuning system for Nuclear Magnetic Resonance (NMR) spectroscopy. Developed using LabVIEW software, the system is designed for the top-tuning configurations of NMR probes commonly used in solid-state physics for broad-frequency-sweep spectra at very low temperatures and/or high magnetic fields. The system integrates a stepper motor, driver, phase shifter, and network analyzer to enable rapid, precise, and efficient probe tuning. Traditional manual tuning for broadband NMR is labor-intensive and time-consuming, often hindering timely data acquisition. Our automated solution significantly reduces tuning time and minimizes user intervention, thereby enhancing the efficiency and accuracy of NMR measurements. The system's effectiveness is demonstrated with experimental ⁶³Cu and ⁶⁵Cu NMR results from an SrCu₂(BO₃)₂ sample in a high magnetic field. This automation is particularly valuable for streamlining research in ultra-high magnetic fields, which are exceptionally expensive to produce.

Palabras clave:

Ajuste automático de frecuencia Espectroscopia RMN de banda ancha Campo magnético alto LabVIEW Configuración de ajuste superior

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