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Sensor electroquímico basado en polímero de impresión molecular de hidrogel en electrodos de carbono serigrafiados

Launa Silky Karenindra Rokhmat¹, Irkham², Putra Rafli Ramdani¹

¹Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang, 45363, Indonesia.

Biosensors & bioelectronics

|February 4, 2026

Resumen

Este estudio desarrolló un novedoso sensor de hidrogel para la detección de hemoglobina glicosilada (HbA1c). El avanzado sensor de polímero de impresión molecular ofrece un método sensible, selectivo y estable para la monitorización de la diabetes.

Área de la Ciencia:

Ingeniería Biomédica; Química Analítica; Ciencia de Materiales

Sus antecedentes:

La hemoglobina glicosilada (HbA1c) es crucial para el diagnóstico y manejo de la diabetes.; Los métodos actuales de detección de HbA1c son precisos pero carecen de portabilidad para el uso en el punto de atención.; Los sensores electroquímicos presentan una alternativa prometedora para diagnósticos accesibles.

Objetivo del estudio:

Diseñar un sensor de polímero de impresión molecular (MIP) a base de hidrogel para el reconocimiento selectivo de HbA1c.; Utilizar modelado computacional para guiar el diseño racional del sensor MIP.; Desarrollar un sensor electroquímico robusto y estable para la monitorización de HbA1c.

Principales métodos:

Modelado computacional (acoplamiento molecular y dinámica) para el diseño de MIP.; Fabricación de un sensor MIP de hidrogel en un electrodo de carbono serigrafiado modificado con oro.; Caracterización mediante FTIR, XPS, SEM y métodos electroquímicos con K3[Fe(CN)6].; Evaluación del rendimiento, incluida la linealidad, LOD, selectividad, estabilidad y análisis de muestras reales.

Principales resultados:

El sensor SPCE/Au/MIPs demostró un amplio rango lineal (10-10^5 ng/mL) y un bajo LOD (1.13 ng/mL).; Alta selectividad (98.7%) y factor de impresión (4.96) confirmaron un reconocimiento molecular eficaz.; El sensor mantuvo el 94% de retención de señal durante 120 días, mostrando una excelente estabilidad a largo plazo.; El análisis de muestras reales mostró una recuperación del 95-112%, comparable a los métodos estándar de HPLC.

Conclusiones:

La plataforma MIP de hidrogel ofrece una solución sensible, selectiva y duradera para la monitorización de HbA1c.; Esta tecnología apoya los diagnósticos de diabetes accesibles, contribuyendo a mejores resultados de salud.; La integración del diseño computacional y la ingeniería MIP proporciona un enfoque robusto para el desarrollo de biosensores.

Palabras clave:

Sensores electroquímicos Hemoglobina glicosilada Estabilidad a largo plazo Polímeros de impresión molecular Diagnóstico en el punto de atención Electrodo de carbono serigrafiado

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