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Updated: Feb 6, 2026

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Shiny-Calorie: una aplicación consciente del contexto para el análisis y la visualización de datos de calorimetría

Stephan Grein1, Tabea Elschner2,3, Ronja Kardinal4

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Shiny-Calorie es una aplicación de código abierto que integra y analiza datos de calorimetría indirecta de diversas plataformas. Esta herramienta mejora la reproducibilidad y la transparencia en la investigación de fenotipado metabólico.

Palabras clave:
calorimetría indirectafenotipado metabólicoRShinybioinformáticaanálisis de datosvisualización de datosinvestigación preclínicametabolismo energético

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Área de la Ciencia:

  • Fenotipado metabólico
  • Bioinformática
  • Investigación animal.

Sus antecedentes:

  • La calorimetría indirecta es crucial para el fenotipado metabólico en la investigación preclínica.
  • Las plataformas existentes carecen de software flexible y fácil de usar para la integración y el análisis de datos.
  • Se necesita un enfoque unificado para diversos datos de fenotipado metabólico.

Objetivo del estudio:

  • Presentar Shiny-Calorie, una aplicación de código abierto para datos de calorimetría indirecta.
  • Permitir la integración transparente de datos/metadatos, análisis estadístico y visualización.
  • Optimizar los flujos de trabajo de análisis y mejorar la reproducibilidad en estudios metabólicos.

Principales métodos:

  • Desarrollada Shiny-Calorie, una aplicación interactiva utilizando GNU R.
  • Implementado soporte para formatos de datos estándar de las principales plataformas comerciales (TSE, Sable Systems, COSMED, CLAMS/Columbus).
  • Integrados métodos estadísticos avanzados para pruebas de hipótesis e interpretación de fenotipos.

Principales resultados:

  • Shiny-Calorie admite diversos formatos de datos y permite la exportación de datos estandarizada.
  • La aplicación facilita la exploración intuitiva de conjuntos de datos longitudinales complejos y multimodales.
  • Incorpora métodos estadísticos robustos para analizar fenotipos del metabolismo energético.

Conclusiones:

  • Shiny-Calorie proporciona una solución flexible, extensible y fácil de usar para el análisis de datos de calorimetría indirecta.
  • La aplicación mejora la transparencia y la reproducibilidad en el fenotipado metabólico.
  • Facilita la interpretación biológicamente significativa del metabolismo y el gasto energético.