Video Experimental Relacionado
Updated: Feb 7, 2026
08:34
Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
1.3K
Bacilo de Bacillus Clausii Protege contra la Disfunción Reproductiva Inducida por Amoxicilina a través de la
Nadia A El-Fahla1, Nahla S El-Shenawy2, Noran M Tawfik3
1Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt. nadiaahmed_90@yahoo.com.
Probiotics and antimicrobial proteins
|February 5, 2026
Resumen
La exposición al antibiótico Amoxicilina (AMO) daña la salud reproductiva masculina al aumentar el estrés oxidativo y reducir la testosterona. El probiótico Bacillus clausii protege contra estos efectos tóxicos, mejorando la salud reproductiva.
Área de la Ciencia:
- Toxicología Reproductiva
- Microbiología
- Salud Ambiental
Sus antecedentes:
- Los antibióticos se usan ampliamente en la agricultura animal, lo que lleva a la acumulación ambiental y a posibles riesgos para la salud humana.
- La investigación emergente sugiere que los antibióticos pueden alterar las hormonas reproductivas masculinas, pero los mecanismos no se comprenden completamente.
Objetivo del estudio:
- Investigar el impacto de la exposición a amoxicilina (AMO) en la salud reproductiva masculina.
- Evaluar el potencial protector de Bacillus clausii contra la toxicidad inducida por AMO.
Principales métodos:
- Los ratones machos se dividieron en cuatro grupos: control, B. clausii, AMO y AMO + B. clausii.
- Los tratamientos se administraron diariamente por gavaje durante 45 días.
- Se evaluaron los marcadores de estrés oxidativo en suero, los niveles de testosterona, la histología testicular y la expresión génica del objetivo mecanicista de la rapamicina (mTOR).
Principales resultados:
- La exposición a AMO aumentó el estrés oxidativo, disminuyó los niveles de testosterona, indujo daño testicular y downregulated la expresión de mTOR.
- La suplementación con B. clausii contrarrestó los efectos negativos de AMO, reduciendo los marcadores de estrés oxidativo y mejorando los niveles de testosterona y la histología testicular.
- El tratamiento con B. clausii upregulated la expresión de mTOR, sugiriendo un papel protector.
Conclusiones:
- La amoxicilina representa un riesgo significativo para la salud reproductiva masculina a través del estrés oxidativo y la alteración hormonal.
- Bacillus clausii demuestra un efecto protector contra la toxicidad de la amoxicilina en el sistema reproductivo masculino.
- Las propiedades antioxidantes del probiótico y su potencial para modular la señalización de mTOR contribuyen a su papel protector.
Videos de Conceptos Relacionados
01:27Reproductive Cloning
32.8K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.8K
03:14Oxidation Numbers
42.9K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.9K
02:38Asexual Reproduction
37.5K
Asexual reproduction allows plants to reproduce without growing flowers, attracting pollinators, or dispersing seeds. Offspring are genetically identical to the parent and produced without the fusion of male and female gametes.
37.5K
01:31Overview of the Reproductive System
5.5K
The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
5.5K
01:15Pyruvate Oxidation
169.0K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
169.0K
02:02Responses to Salt Stress
14.6K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.6K