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Updated: Feb 7, 2026
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Tratamiento fuera de indicación de dermatitis atópica y psoriasis
Julia Sternicka-Rohde1,2, Leszek Bieniaszewski3, Roman J Nowicki1,2
1Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
The Journal of dermatological treatment
|February 6, 2026
Resumen
La prescripción fuera de indicación es común para la dermatitis atópica y la psoriasis. La combinación de tratamientos dentro y fuera de indicación mejoró los resultados de los pacientes más que la monoterapia dentro de indicación.
Área de la Ciencia:
- Dermatology; Clinical Pharmacology
Sus antecedentes:
- Off-label prescribing is frequently necessary in dermatology due to limitations of approved treatments.
- Atopic dermatitis and psoriasis management often require therapies beyond approved indications.
Objetivo del estudio:
- To evaluate the utilization and impact of off-label treatments in patients with atopic dermatitis and psoriasis.
- To assess the effectiveness of combined on-label and off-label therapies compared to standard care.
Principales métodos:
- Retrospective analysis of 5072 patient records from Northern Poland (2014-2024).
- Inclusion criteria: patients diagnosed with atopic dermatitis and/or psoriasis.
Principales resultados:
- 62.5% of atopic dermatitis patients and 25.7% of psoriasis patients received off-label treatment.
- Off-label therapy use inversely correlated with patient age.
- Combined therapy showed greater reductions in EASI, PASI, and DLQI scores, with significant PASI improvement.
Conclusiones:
- Off-label treatment is prevalent and effective for atopic dermatitis and psoriasis.
- Real-world evidence supports evidence-based implementation of off-label therapies in clinical practice.
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