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Updated: Feb 7, 2026

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Mind the GARP: Cómo los glucocorticoides desatan las células T contra el melanoma

Merel Roest¹, Nuno Padrão¹, Wilbert Zwart¹

¹Department of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Cancer discovery

|February 6, 2026

Abstract:

Earnshaw and colleagues discover a tumor-intrinsic mechanism driven by glucocorticoid receptor (GR) activation, in which GR downregulates glycoprotein A repetitions predominant (GARP), thereby inhibiting TGFβ signaling and releasing CD8+ T cells to exert their antitumor activity. This mechanistic insight significantly advances our understanding of how GR shapes tumor immunity and highlights new avenues for overcoming immune checkpoint blockade resistance in melanoma and other cancers. See related article by Earnshaw et al., p. 345.

Palabras clave:

glucocorticoides receptor de glucocorticoides GARP TGFβ células T CD8+inmunidad antitumoral melanoma resistencia inmune bloqueo de puntos de control inmunitario microambiente tumoral

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