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Terpenoides fluorados y sus derivados que contienen flúor

Muhammad Badrul Huda^1,2, Nurlelasari¹, Unang Supratman^1,3

¹Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran Jl. Raya Bandung-Sumedang Km 21 Sumedang 45363 West Java Indonesia y.p.budiman@unpad.ac.id.

|February 6, 2026

Resumen

Los terpenoides fluorados se sintetizan utilizando diversas estrategias para mejorar las propiedades de los fármacos. Esta revisión cubre métodos para crear estas moléculas únicas en diferentes subclases de terpenos.

Área de la Ciencia:

Química Orgánica
Química Medicinal
Química de Productos Naturales

Sus antecedentes:

La incorporación de flúor modifica las propiedades moleculares, mejorando las aplicaciones farmacéuticas.
Los terpenoides son una clase diversa de productos naturales con una bioactividad significativa.
Las moléculas orgánicas fluoradas que se encuentran en la naturaleza son raras, lo que impulsa el interés sintético.

Objetivo del estudio:

Revisar las estrategias sintéticas para terpenoides fluorados.
Cubrir la fluoración en varias subclases de terpenos (mono-, sesqui-, di-, tri-, tetranorterpenos).
Destacar el potencial de los terpenoides fluorados en el descubrimiento de fármacos.

Principales métodos:

Resumen de las metodologías sintéticas existentes.
Clasificación de las estrategias según la subclase de terpeno.
Análisis de los enfoques para introducir flúor en las estructuras de terpenoides.

Principales resultados:

Existen diversas rutas sintéticas para preparar terpenoides fluorados.
La fluoración puede modular la bioactividad de los andamios de terpenoides.
La revisión abarca una amplia gama de estructuras de terpenos.

Conclusiones:

La fluoración sintética es clave para ampliar la utilidad de los terpenoides en la medicina.
El desarrollo de métodos de fluoración eficientes es crucial para acceder a nuevos candidatos a fármacos.
Los terpenoides fluorados ofrecen vías prometedoras para la investigación farmacéutica.

Palabras clave:

terpenoides fluorados química medicinal descubrimiento de fármacos síntesis orgánica productos naturales

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