Video Experimental Relacionado

Updated: Feb 7, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Published on: August 14, 2012

Cirugía de conversión tras quimioterapia en un tumor de diseminación lateral en estadio IV con mutación BRAF V600E y

Reona Kawamura¹, Naoya Toyoshima¹, Masau Sekiguchi¹

¹Endoscopy Division National Cancer Center Hospital Tokyo Japan.

|February 6, 2026

Abstract:

We report a rare case of a BRAF V600E-mutated laterally spreading tumor, granular type (LST-G), with a neuroendocrine carcinoma (NEC) component in a patient with stage IV colorectal cancer. The patient presented with multiple lymph nodes and liver metastases. Following systemic chemotherapy, significant regression of both the primary lesion and metastases was achieved, enabling successful conversion surgery. Postoperative pathological analysis post-surgery revealed only well-differentiated tubular adenocarcinoma, with complete disappearance of the NEC component. Molecular testing confirmed the persistence of the BRAF V600E mutation. The patient remains recurrence-free two years after surgery. This case highlights the potential for conversion surgery in stage IV BRAF-mutated colorectal cancer with NEC.

Palabras clave:

BRAF cirugía de conversión tumor de diseminación lateral tipo granular (LST-G)carcinoma neuroendocrino (NEC)quimioterapia sistémica

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