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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
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Descubrimiento de firmas proteogenómicas urinarias asociadas con el carcinoma de células escamosas de cabeza y cuello
Oriana Barros1,2,3, Joaquim Castro Silva4, Eurico Monteiro4,5
1iBiMED, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Molecular omics
|February 6, 2026
Resumen
Los investigadores identificaron biomarcadores potenciales para la detección temprana del carcinoma de células escamosas de cabeza y cuello (CCECC) mediante el análisis de proteínas en la orina. Este enfoque proteogenómico no invasivo muestra una gran promesa para el manejo y diagnóstico temprano del CCECC.
Área de la Ciencia:
- Urología; Oncología; Proteómica
Sus antecedentes:
- El carcinoma de células escamosas de cabeza y cuello (CCECC) presenta un desafío clínico significativo, caracterizado por un comportamiento agresivo y un mal pronóstico en etapas avanzadas.
- El diagnóstico tardío contribuye frecuentemente a la detección tardía, lo que limita la eficacia de las intervenciones de tratamiento para el CCECC.
- Existe una necesidad crítica de mejorar los métodos para el diagnóstico temprano del CCECC para mejorar los resultados de los pacientes.
Objetivo del estudio:
- Investigar el potencial de la proteogenómica urinaria para la detección temprana del CCECC.
- Identificar nuevos biomarcadores de proteínas en la orina asociados con el CCECC.
- Explorar la viabilidad de utilizar la orina como medio no invasivo para el perfil molecular del CCECC.
Principales métodos:
- Análisis de muestras de orina de pacientes varones con CCECC y sujetos varones sanos mediante proteómica basada en espectrometría de masas.
- Identificación y comparación cuantitativa de proteínas detectadas en muestras de orina.
- Referenciación cruzada proteogenómica de péptidos identificados con bases de datos de variantes de cáncer.
- Análisis funcional de proteínas identificadas para comprender su papel en procesos relacionados con tumores.
Principales resultados:
- Se identificaron 1427 proteínas en la orina; 351 se detectaron de manera consistente en todos los sujetos.
- Se destacaron marcadores pronósticos potenciales, incluidos RNASE1, LRG1 y CD44.
- Se detectaron variantes de proteínas asociadas con CCECC (p. ej., GAA p.(Trp746Cys), SIAE p.(Pro210Leu)) en la orina, lo que sugiere indicadores potenciales de enfermedad avanzada.
- Las proteínas identificadas se vincularon con procesos tumorales clave como la transición epitelio-mesénquima y la desgranulación de neutrófilos.
Conclusiones:
- La orina es un biofluido viable para el perfil proteogenómico no invasivo en el CCECC.
- La proteogenómica urinaria ofrece una vía prometedora para el desarrollo de biomarcadores para la detección temprana del CCECC.
- Se necesita una mayor validación en cohortes más grandes y diversas para confirmar la especificidad y la utilidad clínica de estos hallazgos para el manejo del CCECC.
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