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Identificación de Factores Estructurales que Rigen la Actividad Fotodinámica de las Ftalocianinas

Magdalena Kozlikova1, Mary Angelia Alfred1, Miloslav Machacek1

  • 1Faculty of Pharmacy in Hradec Kralove, Charles University, Ak. Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic.

Journal of medicinal chemistry
|February 6, 2026
PubMed
Resumen

Este estudio estandarizó las comparaciones de terapia fotodinámica (PDT) para más de 40 ftalocianinas (Pcs) y fotosensibilizadores (PSs). Las estructuras anfífilas y las Pcs monoméricas mejoraron significativamente la eficacia de la PDT, ofreciendo principios de diseño para mejores tratamientos contra el cáncer.

Palabras clave:
terapia fotodinámicaftalocianinasfotosensibilizadoresrelaciones estructura-actividaddiseño de fármacostratamiento del cáncer

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