Video Experimental Relacionado

Updated: Feb 8, 2026

Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

Published on: January 7, 2010

Neoplasias Cutáneas Primarias con Fusiones del Gen NUT

Nicolas Macagno¹, Mélanie Legrand², Thibault Kervarrec²

¹Department of Pathology, La Timone Hospital, AP-HM, Marseille, France.

Surgical pathology clinics

|February 6, 2026

Resumen

Este estudio investiga las fusiones del gen NUTM1 en tumores cutáneos como el poroma y el carcinoma NUT. El diagnóstico preciso del carcinoma NUT cutáneo primario depende de pruebas específicas para distinguirlo de otros cánceres.

Área de la Ciencia:

Oncología; Dermatopatología; Patología Molecular

Sus antecedentes:

Las fusiones del gen NUTM1 están implicadas en diversas neoplasias. Las neoplasias cutáneas presentan desafíos diagnósticos, especialmente cuando imitan otras afecciones.

Objetivo del estudio:

Examinar neoplasias cutáneas asociadas con fusiones del gen NUTM1. Destacar las dificultades diagnósticas para distinguir el carcinoma NUT cutáneo primario de entidades similares.

Principales métodos:

Revisión de casos de neoplasias cutáneas con fusiones del gen NUTM1. Análisis de criterios diagnósticos, incluyendo inmunohistoquímica (NUT, SOX10, YAP1) y pruebas moleculares.

Principales resultados:

Se identifican el poroma, el porocarcinoma y el carcinoma NUT cutáneo primario como entidades con fusiones del gen NUTM1. La diferenciación entre el carcinoma NUT cutáneo primario, el carcinoma NUT extracutáneo y el porocarcinoma es compleja.

Conclusiones:

La inmunohistoquímica y las pruebas moleculares son cruciales para un diagnóstico preciso. La distinción del carcinoma NUT cutáneo primario requiere una evaluación cuidadosa para diferenciarlo del carcinoma NUT extracutáneo y del porocarcinoma.

Palabras clave:

NUTM1 NUTM2B Porocarcinoma Poroma Carcinoma NUT cutáneo primario YAP1

Más Videos Relacionados

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

Videos de Conceptos Relacionados

Nuclear Fusion

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...

Gene Families

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...

Tagging and Fusion Proteins

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...

SNAREs and Membrane Fusion

SNAREs and Membrane Fusion

Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...

Gene Flow

Gene Flow

Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.

Genome Size and the Evolution of New Genes

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.