Video Experimental Relacionado

Updated: Feb 8, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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Ikaros y Aiolos: Moduladores de la ligasa E3 de Cereblón de Próxima Generación en Mieloma Múltiple

Maria Eugenia Alvaro1, Enrica Antonia Martino1, Santino Caserta1

  • 1Department of Onco-Hematology, AO of Cosenza, Hematology Unit, Cosenza, Italy.

European journal of haematology
|February 6, 2026
PubMed
Resumen

Nuevos moduladores de la ligasa E3 de cereblón (CELMoD) como la iberdomida y la mezigdomida ofrecen esperanza para pacientes con mieloma múltiple (MM) refractarios a terapias estándar. Estos agentes degradan proteínas clave, superando potencialmente la resistencia y mejorando las respuestas inmunitarias.

Palabras clave:
Moduladores de la ligasa E3 de Cereblón (CELMoD)Resistencia/inmunomodulación de IMiDIberdomidaMezigdomidaMieloma múltiple

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