Video Experimental Relacionado

Updated: Feb 8, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

Centratherin Exhibe Actividad Antitumor contra Células de Glioblastoma

Bruna Mafra de Faria¹, Fernanda Leme da Silva Pinheiro¹, Isabelle Medeiros¹

¹Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Neurochemical research

|February 7, 2026

Resumen

Centratherin, un compuesto natural, muestra un potencial significativo contra el glioblastoma (GB) al reducir la viabilidad de las células cancerosas y dificultar la migración. Este agente se dirige selectivamente a las células de GB, ofreciendo una nueva vía prometedora para tratar este agresivo tumor cerebral.

Área de la Ciencia:

Neurooncología
Química de Productos Naturales
Biología Molecular

Sus antecedentes:

El glioblastoma (GB) es un tumor cerebral agresivo con mal pronóstico a pesar de la terapia estándar con temozolomida (TMZ).
Se necesitan urgentemente nuevas estrategias terapéuticas para superar la resistencia del GB a la apoptosis y su naturaleza invasiva.

Objetivo del estudio:

Investigar el potencial antitumoral de la centratherin, una lactona sesquiterpénica, contra el glioblastoma.
Evaluar los efectos de la centratherin sobre la viabilidad, proliferación, migración, invasión y mecanismos de muerte celular de las células de glioblastoma.

Principales métodos:

Prueba de centratherin en líneas celulares de glioblastoma establecidas y derivadas de pacientes, y en astrocitos sanos.
Evaluación de la viabilidad celular, proliferación, migración, invasión, organización del citoesqueleto, daño del ADN y vías de muerte celular (necrosis, necroptosis).

Principales resultados:

Centratherin demostró citotoxicidad dependiente de la dosis contra células de glioblastoma, respetando los astrocitos sanos.
Inhibió la proliferación, migración e invasión de células de glioblastoma y alteró la organización del citoesqueleto.
Centratherin indujo roturas de doble cadena de ADN y muerte celular principalmente a través de necrosis, independientemente de la necroptosis, y no sensibilizó a las células a TMZ.

Conclusiones:

Centratherin exhibe efectos citotóxicos selectivos contra el glioblastoma, dirigidos a fenotipos malignos clave.
Su capacidad para inducir necrosis y alterar las funciones celulares lo convierte en un candidato prometedor para el tratamiento del glioblastoma.
La investigación adicional sobre los mecanismos distintos de la centratherin puede ofrecer ventajas sobre las terapias actuales para el glioblastoma.

Palabras clave:

Actividad antitumoral Muerte celular Centratherin Glioblastoma

Más Videos Relacionados

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain

Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain

Published on: July 29, 2022

Videos de Conceptos Relacionados

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Activation Energy

Activation Energy

Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...

tRNA Activation

tRNA Activation

Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...

Co-activators and Co-repressors

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

Secondary Active Transport

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...