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Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Inertial Frames of Reference01:03

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Newton’s first law is usually considered to be a statement about reference frames. It provides a method for identifying a special type of reference frame: the inertial reference frame. In principle, we can make the net force on a body zero. If its velocity relative to a given frame is constant, then that frame is said to be inertial. So, by definition, an inertial reference frame is a reference frame where Newton's first law holds valid. Newton's first law applies to objects with...
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Non-inertial Frames of Reference01:27

Non-inertial Frames of Reference

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A reference frame accelerating or decelerating relative to an inertial frame is a non-inertial frame. To help understand this, consider what taking off in an airplane, turning a corner in a car, riding a merry-go-round, and the circular motion of a tropical cyclone all have in common. All these systems are accelerating, decelerating, or rotating relative to the Earth; hence, they all are non-inertial frames. All these systems exhibit inertial forces, which merely seem to arise from motion,...
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Membrane Domains

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The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
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Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
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Ribosomal RNA (rRNA) sequence analysis revealed three distinct groups of cells: eukaryotes, bacteria, and archaea. In 1978, Carl R. Woese proposed the concept of domains, a taxonomic level above kingdoms, to differentiate these groups. He suggested that archaea and bacteria, despite their similar appearance, represent separate domains. Domains differ in rRNA, membrane lipid structure, transfer RNA, and antibiotic sensitivity.In this classification, animals, plants, and fungi belong to the...
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Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
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Una arquitectura de referencia de nube-borde para entrelazar dominios digitales de la salud

Adriano Tramontano1, Oscar Tamburis1, Giulio Perillo2

  • 1National Research Council of Italy, Institute of Biostructures and Bioimaging (IBB-CNR), Naples, Italy.

Health informatics journal
|February 7, 2026
PubMed
Resumen

LinkAll es un nuevo modelo arquitectónico para la monitorización remota en tiempo real en salud humana, animal y ambiental. Utiliza Edge-Computing e Internet de las Cosas (IoT) para el análisis integrado de datos, apoyando los objetivos de One (Digital) Health.

Palabras clave:
computación en la nube y en el bordeintercambio de información sanitariainternet de las cosasuna salud

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Área de la Ciencia:

  • Salud Digital
  • Monitorización Ambiental
  • Informática Biomédica

Sus antecedentes:

  • Los sistemas de monitorización remota requieren un análisis integrado de datos en diversos dominios de la salud.
  • Los sistemas existentes a menudo carecen de la flexibilidad para incorporar diversas fuentes de datos y garantizar capacidades de referenciación cruzada.
  • La iniciativa One (Digital) Health enfatiza la interconexión en la monitorización de la salud.

Objetivo del estudio:

  • Introducir LinkAll, un novedoso modelo arquitectónico para el análisis de datos en tiempo real y cruzado.
  • Demostrar la aplicación de LinkAll en distintos escenarios de monitorización remota.
  • Evaluar el rendimiento de LinkAll en términos de integración, recopilación de datos y referenciación cruzada.

Principales métodos:

  • Aprovechamiento de los principios de Edge-Computing e Internet de las Cosas (IoT) para el manejo de datos.
  • Desarrollo de dos sistemas prototipo: uno para la monitorización de la vegetación urbana y otro para la atención domiciliaria de ancianos.
  • Evaluación del rendimiento del sistema en función de la integración con la infraestructura existente, la recopilación de parámetros biofísicos y la referenciación cruzada de datos.

Principales resultados:

  • Ambos sistemas implementados demostraron una enchufabilidad y referenciabilidad cruzada efectivas.
  • LinkAll integró con éxito diversos sensores y dispositivos en las infraestructuras existentes.
  • El modelo proporcionó información en tiempo real y procesable por máquinas, cumpliendo los requisitos de las partes interesadas.

Conclusiones:

  • La enchufabilidad y la referenciabilidad cruzada de LinkAll mejoran la integración de datos para One (Digital) Health.
  • El cumplimiento de los principios FAIR garantiza una gestión de datos sólida y accesible.
  • El modelo arquitectónico apoya la mejora de la toma de decisiones en sistemas de monitorización de la salud interconectados.