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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
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Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
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Transformers como sustrato para la biología estructural

Ashar J Malik1, Stephanie Portelli2, David B Ascher1

  • 1School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia; Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Current opinion in structural biology
|February 7, 2026
PubMed
Resumen
Este resumen es generado por máquina.

Los transformers revelan la "Biología Latente Emergente" (ELB) al representar proteínas en altas dimensiones, simplificando el descubrimiento de patrones. Sin embargo, persisten los desafíos en el modelado de la química y la dinámica para una comprensión completa de las proteínas.

Palabras clave:
biología estructuralbiología computacionalbiofísicaaprendizaje profundomodelos de transformadorespredicción de estructuras de proteínasinteracciones de proteínasefectos de variantesbiología latente emergente

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