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Updated: Feb 10, 2026
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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
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Queratitis Estromal en el Estudio de Enfermedades Oculares por Zóster (ZEDS): Lecciones Aprendidas
Deborah S Jacobs1, TingFang Lee2, Penny Asbell3
1Harvard Medical School, Boston MA.
American journal of ophthalmology
|February 8, 2026
Resumen
La queratitis estromal (QE) en pacientes con herpes zóster oftálmico (HZO) a menudo se resuelve con un seguimiento cercano y tratamiento, manteniendo una buena visión sin antivirales orales. Se recomiendan esteroides tópicos de baja potencia para el manejo de la QE en HZO.
Área de la Ciencia:
- Oftalmología; Virología; Enfermedades Infecciosas
Sus antecedentes:
- El herpes zóster oftálmico (HZO) puede provocar complicaciones oculares, incluida la queratitis estromal (QE).; El Estudio de Enfermedades Oculares por Zóster (ZEDS) investigó la eficacia del valaciclovir oral en pacientes con HZO.
Objetivo del estudio:
- Analizar la presentación, el tratamiento y los resultados visuales de la queratitis estromal (QE) dentro del Estudio de Enfermedades Oculares por Zóster (ZEDS).
Principales métodos:
- Análisis secundario de la QE como punto final en un ensayo clínico aleatorizado de valaciclovir oral versus placebo en pacientes con HZO.; Seguimiento prospectivo durante 18 meses, con evaluación retrospectiva de la presentación de la QE, el tratamiento con esteroides tópicos y la agudeza visual a los 12 meses.
Principales resultados:
- La queratitis estromal (QE) ocurrió en el 20% de los participantes, no relacionada con el tratamiento con valaciclovir.; La agudeza visual se mantuvo estable, sin diferencias significativas entre los grupos de tratamiento.; La mayoría de los casos de QE se detectaron en las visitas programadas; el tratamiento antiviral oral fue infrecuente. El uso de esteroides tópicos varió, y muchos pacientes recibieron esteroides de baja potencia o ajustes de dosis.
Conclusiones:
- Los pacientes con QE relacionada con HZO generalmente mantienen una buena visión con monitorización y tratamiento rápido, a menudo sin antivirales orales.; Se sugieren esteroides tópicos de baja potencia para el manejo y la supresión de la QE en pacientes con HZO.
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