Video Experimental Relacionado

Updated: Feb 10, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

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Published on: July 21, 2023

Bacteriófagos derivados de despolimerasas como sinérgicos antimicrobianos: una estrategia para superar la resistencia

Shuhong Han^1,2,3, David H Yang⁴, Jiayin Shen^1,2,3

¹National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.

Bioscience trends

|February 8, 2026

Abstract:

Upon infection, bacteria form polysaccharides barriers, such as capsular polysaccharide (CPS), exopolysaccharide (EPS) and lipopolysaccharide (LPS). The barrier hinders antibiotic penetration and host immune clearance, exacerbating antimicrobial resistance crisis. Bacteriophages (phages), natural viruses that can specifically infect and kill bacteria, have evolved depolymerase to degrade the polysaccharides. This review evaluates the primary therapeutic value of depolymerases as synergists to existing therapies, systematically detailing their potential to enhance antibiotic efficacy, improve phage therapy, and augment host immunity. We further integrate an evolutionary perspective to analyze likely adaptive responses and potential strategies to eradicate resistance. Finally, the discussion addresses formulation challenges and future prospects for the clinical translation of depolymerase-based synergistic therapies.

Palabras clave:

reactivo antibacteriano reversión de la resistencia a los antibióticos bacteriófagos dispersión de biopelículas terapia combinada despolimerasa polisacárido evolución de la resistencia

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