Video Experimental Relacionado

Updated: Feb 10, 2026

Live Imaging of Mouse Secondary Palate Fusion

Live Imaging of Mouse Secondary Palate Fusion

Published on: July 27, 2017

Momento de la fusión del paladar secundario en embriones y fetos humanos

Puck Pauline Mulder^1,2, Jess Johanna Peters^2,3, Yousif Dawood^1,2,4

¹Department of Obstetrics and Gynecology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands.

Birth defects research

|February 8, 2026

Resumen

El desarrollo del paladar secundario humano ocurre entre las etapas de Carnegie 18-23, con contacto de las crestas en CS23. Esta ventana crítica resalta los riesgos de la exposición a medicamentos durante el embarazo temprano para la formación del paladar.

Área de la Ciencia:

Biología del Desarrollo
Embriología Humana
Anomalías Congénitas

Sus antecedentes:

El desarrollo facial involucra derivados del arco faríngeo; las interrupciones causan labio leporino/paladar hendido (CL/P).
El CL/P afecta la alimentación, el habla y el bienestar psicosocial.
Comprender la formación del paladar secundario es clave para la patogénesis del CL/P.

Objetivo del estudio:

Evaluar el momento y la morfología del desarrollo del paladar secundario humano.
Enfocado en embriones (Etapas de Carnegie 17-23) y fetos (9-11 semanas PC).

Principales métodos:

Análisis de secciones histológicas y escáneres de micro-CT.
Se examinaron 26 especímenes humanos en etapas clave de desarrollo.

Principales resultados:

Las crestas palatinas aparecen en la Etapa de Carnegie 18, con un crecimiento vertical hasta la CS22.
Reorientación horizontal y extensión medial ocurren en la CS22.
Contacto de las crestas (inicio de la fusión) observado en la CS23, completado a las 9 semanas PC.

Conclusiones:

Cronograma refinado del desarrollo del paladar secundario humano.
Identificó una ventana crítica de desarrollo (CS17-23).
Recomienda la reevaluación de las pautas de administración de medicamentos durante el embarazo temprano debido a posibles riesgos teratogénicos.

Palabras clave:

labio leporino y paladar hendido (CL/P)histología embriones humanos fetos humanos microtomografía computarizada (micro-CT)fusión de las crestas palatinas desarrollo del paladar secundario

Más Videos Relacionados

Method of Studying Palatal Fusion using Static Organ Culture

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae

Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae

Published on: June 11, 2016

Videos de Conceptos Relacionados

Development of the Sexual Organs in the Embryo and Fetus

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...

Nuclear Fusion

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...

Secondary Active Transport

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...

Secondary Active Transport

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...

Secondary Healthcare System

Secondary Healthcare System

Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...

Primary and Secondary Growth in Roots and Shoots

Primary and Secondary Growth in Roots and Shoots

Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.