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Perfilación de pacientes con enfermedad pulmonar obstructiva crónica de alto riesgo para terapia triple: ¿Quién la
Alfian Nur Rosyid1,2, Arief Bakhtiar1,3, Daniel Maranatha1,3
1Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Annals of African medicine
|February 8, 2026
Resumen
La terapia triple para la enfermedad pulmonar obstructiva crónica (EPOC) es necesaria en pacientes con recuentos elevados de eosinófilos, exacerbaciones graves y mala calidad de vida. La evaluación multidimensional guía el manejo individualizado de la EPOC.
Área de la Ciencia:
- Neumología; Medicina Clínica
Sus antecedentes:
- La enfermedad pulmonar obstructiva crónica (EPOC) representa una carga significativa para la salud mundial. La identificación de características clínicas y biomarcadores es crucial para estrategias de tratamiento efectivas de la EPOC.
Objetivo del estudio:
- Determinar los factores clínicos asociados con la necesidad de terapia triple en pacientes con EPOC.
Principales métodos:
- Se realizó un estudio observacional y transversal. Se analizaron datos de 50 pacientes varones con EPOC (≥40 años) con espirometría y evaluación clínica. La significancia estadística se estableció en P < 0,05.
Principales resultados:
- La terapia triple se relacionó con niveles elevados de eosinófilos en sangre (P < 0,001), exacerbaciones graves (P = 0,001) y deterioro de la calidad de vida. Las comorbilidades como el infarto de miocardio y la clasificación en el Grupo E del Riesgo de Limitación del Flujo Aéreo, Carga de Síntomas y Exacerbación (ABE) fueron significativas. La mayoría de los pacientes eran mayores, fumadores empedernidos, con síntomas moderados y limitaciones funcionales.
Conclusiones:
- La terapia triple está indicada para pacientes con EPOC con recuentos de eosinófilos ≥300 células/μL, antecedentes de exacerbaciones graves y aquellos en el Grupo E de ABE. Estos pacientes a menudo tienen una calidad de vida reducida y una mayor carga de comorbilidades. Los hallazgos respaldan el énfasis del Ensayo WISDOM en la evaluación integral para una atención personalizada de la EPOC.
Palabras clave:
EPOCEnfermedad pulmonar obstructiva crónicaeosinófiloexacerbacióncalidad de vidaqualité de vieterapia tripletriple therapyéosinophilesMás Videos Relacionados
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