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Updated: Feb 10, 2026
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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
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Una sonda fluorescente NIR funcionalizada con cumarina basada en el esqueleto de tiopirona para la detección de Cys y
Huan Zhang1, Baoze Guo1, Junqing Zhou1
1Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China. youlai@tjut.edu.cn.
Analytical methods : advancing methods and applications
|February 9, 2026
Resumen
Una nueva sonda fluorescente basada en tiopirona ofrece una detección sensible y rápida de la cisteína. Esta herramienta es prometedora para la obtención de imágenes biológicas y el análisis conveniente basado en teléfonos móviles en varias muestras.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Biología Molecular Biología Molecular
- Sensores químicos de detección de sustancias químicas.
Sus antecedentes:
- Las sondas fluorescentes de cisteína son vitales para la detección sensible de la cisteína.
- Las aplicaciones actuales abarcan el monitoreo de enfermedades, el equilibrio redox y los estudios de toxicidad de medicamentos.
Objetivo del estudio:
- Diseñar y caracterizar una nueva sonda fluorescente para la detección de cisteína.
- Para evaluar su desempeño en sistemas biológicos y muestras del mundo real.
Principales métodos:
- Desarrollo de una sonda fluorescente basada en tiopirona.
- Caracterización de las propiedades fotofísicas (sensibilidad, tiempo de respuesta, selectividad).
- Pruebas de aplicación en líneas celulares (RAW 264.7), pez cebra y muestras reales.
Principales resultados:
- La sonda exhibe un gran desplazamiento de Stokes (217 nm) y una alta sensibilidad (13,60 nM).
- Demuestra un tiempo de respuesta rápido (3,0 min), alta estabilidad y selectividad.
- Aplicación exitosa en imágenes celulares, estudios in vivo y análisis de muestras.
Conclusiones:
- La nueva sonda fluorescente es efectiva para la detección sensible y selectiva de cisteína.
- Su utilidad está validada en modelos biológicos y análisis prácticos de muestras.
- Potencial para una prueba conveniente del nivel de cisteína utilizando el software del teléfono móvil.
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