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Sepsis pediátrica asociada a viremia por bocavirus humano 1 con un curso urinario trifásico: un informe de caso
Shuwen Zhong1, Wenjie Shan1, Long Xiang2
1International Medical Department, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Translational pediatrics
|February 9, 2026
Resumen
El bocavirus humano 1 (HBoV1) puede causar sepsis pediátrica como único patógeno. Este caso mostró un curso urinario trifásico único, destacando el impacto sistémico del HBoV1 y la necesidad de diagnósticos avanzados.
Área de la Ciencia:
- Enfermedades infecciosas pediátricas.
- Virología Virología.
- Medicina de cuidados críticos Medicina de cuidados críticos.
Sus antecedentes:
- El bocavirus humano 1 (HBoV1) es un virus respiratorio pediátrico común.
- Su papel como única causa de enfermedades sistémicas graves y sus efectos en el sistema urinario no se comprenden completamente.
Objetivo del estudio:
- Para informar el primer caso de sepsis pediátrica causada por la viremia HBoV1.
- Para describir un nuevo curso urinario trifásico en este paciente.
Principales métodos:
- Informe de caso de una niña de 4 años con sepsis.
- Secuenciación metagenómica de sangre de próxima generación (mNGS) para la identificación de patógenos.
- Ultrasonografía del tracto urinario y evaluación del volumen residual post-vacío (PVR).
Principales resultados:
- Viremia HBoV1 de alta carga identificada como el único patógeno en la sepsis con cultivo negativo.
- El paciente exhibió un curso urinario trifásico: piruria estéril, imágenes normales durante la sepsis y pielectasis retrasada / aumento de PVR.
- Las anomalías urinarias se resolvieron en 2,5 meses.
Conclusiones:
- El HBoV1 puede ser el único patógeno que causa sepsis pediátrica.
- Los hallazgos urinarios sugieren una patogénesis mediada por inflamación.
- El diagnóstico avanzado y la vigilancia longitudinal son cruciales para identificar la sepsis viral y el manejo de la disfunción orgánica potencial.
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