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La correlación entre el índice de hiperemia reactiva y los marcadores de disfunción endotelial en pacientes con

Chaoping Yu^1,2, Yue Liu¹, Fengcheng Xu^1,2

¹Department of Cardiology, The Third Affiliated Hospital of Chengdu Medical College, Chengdu Pidu District People's Hospital, Chengdu, China.

Frontiers in cardiovascular medicine

|February 9, 2026

Resumen

Este estudio encontró que el índice de hiperemia reactiva (RHI) puede predecir la lesión endotelial vascular en pacientes con hipertensión y síndrome de hipopnea de apnea obstructiva del sueño (OSAHS). El RHI es un indicador valioso para evaluar la disfunción endotelial en esta población de alto riesgo.

Área de la Ciencia:

Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
Medicina del sueño Medicina del sueño.
Biología Vascular Biología Vascular

Sus antecedentes:

La disfunción endotelial es un factor crítico en las enfermedades cardiovasculares.
La hipertensión y el síndrome de hipopnea por apnea obstructiva del sueño (OSAHS) son comorbilidades comunes que exacerban la disfunción endotelial.
Existe la necesidad de herramientas clínicas para estratificar la gravedad de la disfunción endotelial en pacientes con hipertensión coexistente y OSAHS.

Objetivo del estudio:

Investigar el impacto de la hipertensión combinada y el SAASO en la función endotelial vascular.
Para explorar la utilidad del índice de hiperemia reactiva (RHI) en la evaluación de la disfunción endotelial en este grupo de pacientes.

Principales métodos:

Reclutamiento consecutivo de pacientes hipertensos de 35 a 60 años con OSAHS.
La medición del índice de apnea-hipopnea (AHI), RHI, y los marcadores de daño endotelial (VWF, VEGF, EMPs).
Análisis de correlación entre el AHI, el RHI, la gravedad de la hipertensión y los marcadores endotelial.

Principales resultados:

Se encontró una correlación inversa significativa entre el AHI y el RHI (r = -0.58, P < 0.001).
La RHI mostró asociaciones inversas significativas con el VWF (r = -0.62, P < 0.001), el VEGF (r = -0.63, P < 0.001) y los EMP (r = -0.67, P < 0.001).
El aumento de AHI, VWF, VEGF y EMP se asoció con una disminución de RHI, lo que indica un empeoramiento de la disfunción endotelial.

Conclusiones:

El índice de hiperemia reactiva (RHI) es un indicador valioso para evaluar la función endotelial vascular en pacientes con hipertensión y OSAHS.
RHI puede predecir el grado de lesión endotelial vascular en esta población de alto riesgo.
La medición rutinaria del RHI puede ayudar a estratificar la carga de la enfermedad y guiar las estrategias de intervención.

Palabras clave:

El índice apnea-hipopnea es el índice apnea-hipopnea.La hipertensión es la hipertensión.síndrome de apnea obstructiva del sueño-hipopnea.el índice de hiperemia reactiva.La función endotelial vascular tiene una función vascular.

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