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La patogénesis de los biomarcadores de estrés oxidativo en la fibrilación auricular: una revisión narrativa
Hira Naveed1, Aqib Ishaque1, Atif Nadeem1
1Department of Cardiology, Army Cardiac Hospital/CMH Lahore Medical College, Lahore, Pakistan.
The Journal of innovations in cardiac rhythm management
|February 9, 2026
Resumen
El estrés oxidativo (SO) contribuye a la fibrilación auricular (FA) al dañar el tejido cardíaco. Los biomarcadores como la 8-hidroxideoxiguanosina (8-OHdG) y la Eh GSH muestran fuertes vínculos con el desarrollo y la gravedad de la FA.
Área de la Ciencia:
- Cardiología Cardiología.
- La bioquímica es la bioquímica.
- Fisiopatología Fisiopatología.
Sus antecedentes:
- La fibrilación auricular (FA) es la arritmia cardíaca más común.
- El estrés oxidativo (OS) es cada vez más reconocido como un factor clave en la patogénesis de la FA.
- OS puede promover la remodelación auricular y el desarrollo de un sustrato aritmogénico.
Objetivo del estudio:
- Para resumir el papel de varios biomarcadores de OS en la patogénesis de la FA.
- Explorar la asociación entre los marcadores específicos de OS y la gravedad, el riesgo y las complicaciones de la FA.
- Para resaltar áreas para futuras investigaciones en OS y AF.
Principales métodos:
- Revisión de la literatura existente sobre los biomarcadores de OS en AF.
- Análisis de las asociaciones entre biomarcadores específicos (por ejemplo, 8-OHdG, GPx, AGEs, SOD, MDA, IsoPs, Eh GSH, AOPPs) y AF.
- Examen de los niveles de biomarcadores en relación con la gravedad de la FA, la FA posquirúrgica y los eventos tromboembólicos.
Principales resultados:
- Los niveles elevados de 8-hidroxideoxiguanosina (8-OHdG) en plasma se correlacionan con la gravedad de la fibrosis auricular.
- La actividad reducida de la glutatión peroxidasa (GPx) está relacionada con trastornos electroquímicos y daño lipídico.
- El aumento de los niveles de Eh GSH aumenta significativamente el riesgo de AF incidente.
- Los niveles elevados de 8-isoprostano están asociados con eventos tromboembólicos en pacientes con AF que reciben anticoagulantes.
- La actividad elevada de la superóxido dismutasa (SOD) en la FA posquirúrgica puede indicar una respuesta antioxidante compensatoria.
Conclusiones:
- La OS juega un papel importante en la patogénesis de la FA y la remodelación auricular.
- Los biomarcadores específicos de la OS demuestran fuertes asociaciones con la gravedad, el riesgo y las complicaciones de la FA.
- Se necesita más investigación para identificar nuevos marcadores de OS y su potencial terapéutico en el manejo de la FA.
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