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Productos naturales dirigidos a la vía de señalización MAPK: opciones potenciales para el tratamiento de la colitis
Canglin Li1, Zuoqiang Li2, Ya Zheng3
1Medical Management Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in pharmacology
|February 9, 2026
Resumen
Los productos naturales son prometedores para el tratamiento de la colitis ulcerosa (UC) al dirigirse a la vía de señalización MAPK. Estos compuestos ofrecen una alternativa más segura y efectiva a las terapias convencionales para controlar los síntomas y la inflamación de la UC.
Área de la Ciencia:
- Gastroenterología y Hepatología.
- Farmacología y Toxicología.
- Química de Productos Naturales Química de Productos Naturales
Sus antecedentes:
- La colitis ulcerosa (UC) es una enfermedad inflamatoria intestinal crónica que causa una morbilidad significativa en los pacientes y aumenta el riesgo de cáncer colorrectal.
- Los tratamientos actuales como los aminosalicilatos y los glucocorticoides tienen limitaciones que incluyen resistencia a los medicamentos, efectos adversos y inmunosupresión.
- Existe una necesidad crítica de estrategias terapéuticas más seguras y a largo plazo para el manejo de la UC.
Objetivo del estudio:
- Revisar investigaciones recientes sobre productos naturales dirigidos a la vía de señalización MAPK para el tratamiento de la colitis ulcerosa (UC).
- Aclarar los mecanismos por los cuales los productos naturales modulan la inflamación y las respuestas inmunes relacionadas con la UC.
- Proporcionar una base para el desarrollo de nuevas terapias basadas en la medicina natural para la UC.
Principales métodos:
- Búsqueda sistemática de la literatura utilizando las palabras clave "colitis ulcerosa", "MAPK" y "productos naturales" en las bases de datos de PubMed, Web of Science y CNKI.
- Análisis de estudios publicados en la última década, con énfasis en los últimos cinco años.
- Identificación y síntesis de los resultados de 42 estudios relevantes.
Principales resultados:
- Los productos naturales, incluidos los flavonoides, alcaloides, terpenoides y polifenoles, se dirigen efectivamente a la vía de señalización de MAPK.
- Estos compuestos naturales demuestran la capacidad de suprimir la inflamación intestinal, mejorar la función de la barrera intestinal y regular el equilibrio inmunológico en los modelos de UC.
- La evidencia sugiere que los productos naturales ofrecen efectos multi-dirigidos con menor toxicidad y menos efectos secundarios en comparación con los medicamentos UC convencionales.
Conclusiones:
- Los productos naturales dirigidos a la vía MAPK representan una vía terapéutica prometedora para la colitis ulcerosa.
- Se necesitan más investigaciones y estudios de traducción clínica para desarrollar estos agentes naturales en tratamientos viables de UC.
- Esta revisión pone de relieve el potencial de los medicamentos naturales para abordar las necesidades no satisfechas en el largo plazo, el manejo seguro de la UC.
Palabras clave:
El MAPKK es el MAPK.La inflamación es la inflamación de la inflamación.La barrera intestinal es la barrera intestinal.Los productos naturales son productos naturales y los productos naturales son productos naturales.La colitis ulcerosa también se conoce como colitis ulcerosa.Más Videos Relacionados
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